@prefix :      <http://purl.obolibrary.org/obo/ro.owl#> .
@prefix oboInOwl: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix afn:   <http://jena.hpl.hp.com/ARQ/function#> .
@prefix swrlb: <http://www.w3.org/2003/11/swrlb#> .
@prefix swrl:  <http://www.w3.org/2003/11/swrl#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix swrla: <http://swrl.stanford.edu/ontologies/3.3/swrla.owl#> .
@prefix cito:  <http://purl.org/spar/cito/> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix oboInOwl1: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix obo:   <http://purl.obolibrary.org/obo/> .
@prefix foaf:  <http://xmlns.com/foaf/0.1/> .
@prefix subsets: <http://purl.obolibrary.org/obo/ro/subsets#> .
@prefix dc:    <http://purl.org/dc/elements/1.1/> .

obo:RO_0002515  a              owl:ObjectProperty ;
        rdfs:label             "sequentially adjacent to" ;
        rdfs:subPropertyOf     obo:RO_0002527 ;
        obo:IAO_0000112        "Every UTR is adjacent to a CDS of the same transcript" , "Two exons on a processed transcript that were previously connected by an intron are adjacent" , "Two consecutive DNA residues are sequentially adjacent" ;
        obo:IAO_0000115        "x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0000302  a              owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:label             "downstream in neural circuit with"@en ;
        rdfs:subPropertyOf     obo:RO_0000300 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next."@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en ;
        obo:IAO_0000426        "(forall (?x ?y) \n\t(iff \n\t\t(downstream_neural_circuit_path  ?x ?y)\n\t\t(and\n\t\t\t(\"neuron ; CL_0000540\" ?x)\n\t\t\t(\"neuron ; CL_0000540\" ?y)\n\t\t\t(synapsed_by ?x ?y))))\n\n\n(forall (...s ?x ?y ?z) \n\t(iff \n\t\t(downstream_neural_circuit_path ...s ?x ?y ?z )\n\t\t(and\n\t\t\t(downstream_neural_circuit_path ...s ?x ?y)\n\t\t\t(\"neuron ; CL_0000540\" ?z)\n\t\t\t(synapsed_by ?y ?z))))\n\t\t\t\n(forall (?x ?y) \n\t(iff \n\t\t(downstream_in_neural_circuit_with ?x ?y)\n\t\t(exists (...s)\n\t\t\t(downstream_neural_circuit_path  ?x ...s ?y)))) \n\t\t\t" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002304  a           owl:ObjectProperty ;
        rdfs:comment        "holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y" ;
        rdfs:label          "causally upstream of, positive effect" ;
        rdfs:subPropertyOf  obo:RO_0002411 , obo:RO_0004047 ;
        obo:RO_0004049      obo:RO_0002411 ;
        dc:creator          "cjm" .

obo:RO_0002491  a           owl:ObjectProperty ;
        rdfs:comment        "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label          "existence starts and ends during" ;
        rdfs:subPropertyOf  obo:RO_0002492 , obo:RO_0002488 ;
        obo:IAO_0000115     "x existence starts and ends during y if and only if the start of x is part of y and the end of x is part of y. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0003305  a           owl:ObjectProperty ;
        rdfs:label          "contributes to severity of condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003304 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual." ;
        obo:IAO_0000118     "contributes to expressivity of condition" .

obo:RO_0002219  a           owl:ObjectProperty ;
        rdfs:label          "surrounded by"@en ;
        rdfs:subPropertyOf  obo:RO_0002220 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:RO_0001900      obo:RO_0001901 ;
        owl:inverseOf       obo:RO_0002221 .

obo:RO_0004015  a                owl:ObjectProperty ;
        rdfs:label               "is causal susceptibility factor for" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317345> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition  and that is necessary but not sufficient to develop the condition[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:57:43Z"^^xsd:dateTime .

<urn:swrl#y>  a  swrl:Variable .

obo:RO_0002008  a           owl:ObjectProperty ;
        rdfs:comment        "Example: if we define region of chromosome as any subdivision of a chromosome along its long axis, then we can define a region of chromosome that contains only gene x as 'chromosome region' that coincident_with some 'gene x', where the term gene X corresponds to a genomic sequence." ;
        rdfs:domain         []  ;
        rdfs:label          "coincident with" ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000115     "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other." ;
        obo:IAO_0000116     "Note from NCEAS meeting: consider changing primary label" ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002587  a           owl:ObjectProperty ;
        rdfs:label          "results in synthesis of" ;
        rdfs:subPropertyOf  obo:RO_0002297 .

obo:RO_0002461  a           owl:ObjectProperty ;
        rdfs:label          "partner in" ;
        rdfs:subPropertyOf  obo:RO_0000056 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Experimental: relation used for defining interaction relations. An interaction relation holds when there is an interaction event with two partners. In a directional interaction, one partner is deemed the subject, the other the target" .

obo:RO_0002376  a           owl:ObjectProperty ;
        rdfs:label          "tributary of"@en ;
        rdfs:seeAlso        "http://en.wikipedia.org/wiki/Tributary"^^xsd:anyURI ;
        rdfs:seeAlso        <http://dbpedia.org/ontology/drainsTo> ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000112     "inferior epigastric vein tributary_of external iliac vein" , "Deschutes River tributary_of Columbia River" ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "drains into" , "drains to" , "tributary channel of" ;
        obo:IAO_0000119     "http://en.wikipedia.org/wiki/Tributary" , "http://www.medindia.net/glossary/venous_tributary.htm" ;
        obo:IAO_0000232     "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries)"^^xsd:anyURI ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002557  a           owl:ObjectProperty ;
        rdfs:label          "has pathogen" ;
        rdfs:subPropertyOf  obo:RO_0002453 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002431  a           owl:ObjectProperty ;
        rdfs:label          "involved in or involved in regulation of" ;
        rdfs:subPropertyOf  obo:RO_0002500 , obo:RO_0002264 , obo:RO_0002328 ;
        obo:IAO_0000115     "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ;
        obo:IAO_0000116     "OWL does not allow defining object properties via a Union" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "involved in or reguates" .

<urn:swrl#mf>  a  swrl:Variable .

obo:RO_0002612  a           owl:AnnotationProperty ;
        rdfs:label          "axiom has evidence" ;
        rdfs:subPropertyOf  obo:RO_0002611 ;
        obo:IAO_0000115     "A relationship between a sentence and an instance of a piece of evidence in which the evidence supports the axiom" ;
        obo:IAO_0000232     "This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual." .

obo:RO_0002220  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000004 ;
        rdfs:label          "adjacent to"@en ;
        rdfs:range          obo:BFO_0000004 ;
        rdfs:subPropertyOf  obo:RO_0002163 ;
        obo:IAO_0000112     "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." , "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." , "The epidermis layer of a vertebrate is adjacent to the dermis." , "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x adjacent to y if and only if x and y share a boundary." ;
        obo:IAO_0000116     "This relation acts as a join point with BSPO" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:RO_0001900      obo:RO_0001901 .

obo:ro.owl  a           owl:Ontology ;
        rdfs:comment    "Includes Ontology(OntologyID(Anonymous-21)) [Axioms: 32 Logical Axioms: 0]" , "Includes Ontology(OntologyID(Anonymous-21)) [Axioms: 26 Logical Axioms: 0]" ;
        dc:description  "The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies."@en ;
        dc:source       <http://obofoundry.org/ro> ;
        dc:title        "OBO Relations Ontology"@en ;
        owl:imports     <http://purl.obolibrary.org/obo/ro/go-biotic.owl> , <http://purl.obolibrary.org/obo/ro/other_import.owl> , <http://purl.obolibrary.org/obo/ro/pato_import.owl> , <http://purl.obolibrary.org/obo/ro/core.owl> , <http://purl.obolibrary.org/obo/ro/go_cc_import.owl> , <http://purl.obolibrary.org/obo/ro/generated-axioms.owl> , <http://purl.obolibrary.org/obo/ro/go_mf_import.owl> , <http://purl.obolibrary.org/obo/ro/rohom.owl> , <http://purl.obolibrary.org/obo/ro/temporal-intervals.owl> , <http://purl.obolibrary.org/obo/ro/chemical.owl> , <http://purl.obolibrary.org/obo/ro/annotations.owl> , <http://purl.obolibrary.org/obo/ro/el-constraints.owl> ;
        owl:versionIRI  <http://purl.obolibrary.org/obo/ro/releases/2019-02-02/ro.owl> ;
        foaf:homepage   " https://github.com/oborel/obo-relations/"^^xsd:anyURI .

obo:RO_0002527  a              owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label             "does not overlap sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002514 ;
        obo:IAO_0000115        "x does not overlaps the sequence of x if and only if there is no z such that x has a subsequence z and z is a subsequence of y." ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "disconnected from" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0002401  a        owl:ObjectProperty ;
        rdfs:comment     "Likely to be obsoleted. See:\nhttps://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit" ;
        rdfs:label       "obsolete has indirect input" ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000117  "Chris Mungall" ;
        owl:deprecated   true .

obo:CARO_0001010  a  owl:Class .

obo:RO_0002292  a           owl:ObjectProperty ;
        rdfs:label          "expresses"@en ;
        rdfs:subPropertyOf  obo:RO_0002330 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Inverse of 'expressed in'" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002105  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('type Ib terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ;
        rdfs:label             "synapsed_via_type_Ib_bouton_to"@en ;
        rdfs:subPropertyOf     obo:RO_0002120 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton." ;
        obo:IAO_0000117        "David Osumi-Sutherland" , "Marta Costa" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0061176 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf          obo:RO_0002109 .

obo:RO_0004027  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease has inflammation site" ;
        rdfs:range               obo:CARO_0000003 ;
        rdfs:subPropertyOf       obo:RO_0004026 ;
        obo:IAO_0000115          "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-12-26T19:37:31Z"^^xsd:dateTime .

obo:RO_0001019  a           owl:ObjectProperty ;
        rdfs:label          "contains"@en ;
        obo:IAO_0000111     "contains"@en ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002599  a           owl:ObjectProperty ;
        rdfs:label          "capable of inhibiting or preventing pathological process" ;
        rdfs:subPropertyOf  obo:RO_0002597 ;
        obo:IAO_0000112     "pazopanib -> pathological angiogenesis" ;
        obo:IAO_0000115     "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." ;
        obo:IAO_0000118     "treats" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000232     "The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber." .

obo:RO_0008508  a           owl:ObjectProperty ;
        rdfs:label          "has eggs laid on by" ;
        rdfs:subPropertyOf  obo:RO_0002619 ;
        obo:IAO_0000115     "An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation." .

obo:RO_0002081  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002473  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "composed primarily of" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000112     "'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'" ;
        obo:IAO_0000115     "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002388  a           owl:ObjectProperty ;
        rdfs:label          "has potential to directly develop into"@en ;
        rdfs:subPropertyOf  obo:RO_0002387 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y"@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002262  a  owl:ObjectProperty .

obo:RO_0002177  a               owl:ObjectProperty ;
        rdfs:domain             obo:CARO_0000003 ;
        rdfs:label              "attached to part of"@en ;
        rdfs:range              obo:CARO_0000003 ;
        rdfs:subPropertyOf      obo:RO_0002567 , obo:RO_0002323 ;
        obo:IAO_0000115         "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." ;
        obo:IAO_0000589         "attached to part of (anatomical structure to anatomical structure)" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002569  a           owl:ObjectProperty ;
        rdfs:label          "has branching part" ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000115     "inverse of branching part of" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002443  a               owl:ObjectProperty ;
        rdfs:label              "interacts with via parasite-host interaction" ;
        rdfs:subPropertyOf      obo:RO_0002440 ;
        obo:IAO_0000115         "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ;
        obo:IAO_0000232         "This relation groups a pair of inverse relations, parasite of and parasitized by" ;
        obo:RO_0002561          obo:GO_0072519 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002232  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000015 ;
        rdfs:label              "has end location"@en ;
        rdfs:range              obo:BFO_0000004 ;
        rdfs:subPropertyOf      obo:RO_0002479 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "ends with process that occurs in" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002624  a           owl:ObjectProperty ;
        rdfs:label          "lays eggs in" ;
        rdfs:subPropertyOf  obo:RO_0002618 , obo:RO_0002444 ;
        owl:inverseOf       obo:RO_0002625 .

obo:RO_0002539  a           owl:AnnotationProperty ;
        rdfs:label          "start, days post fertilization" ;
        rdfs:subPropertyOf  obo:RO_0002537 ;
        obo:IAO_0000115     "Count of number of days intervening between the start of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 0 for this property." .

obo:RO_0001020  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "is allergic trigger for"@en ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000112     "penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520)" ;
        obo:IAO_0000115     "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
        owl:inverseOf       obo:RO_0001022 .

obo:RO_0002021  a                owl:ObjectProperty ;
        rdfs:label               "occurs across" ;
        rdfs:subPropertyOf       obo:RO_0002479 ;
        obo:IAO_0000115          "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-07-20T17:19:37Z"^^xsd:dateTime .

obo:RO_0002413  a               owl:ObjectProperty ;
        rdfs:label              "directly provides input for"@en ;
        rdfs:subPropertyOf      obo:RO_0002412 , obo:RO_0002414 ;
        obo:IAO_0000114         obo:IAO_0000428 ;
        obo:IAO_0000115         "p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c" ;
        obo:IAO_0000116         "This is currently called 'directly provides input for' to be consistent with our terminology where we use 'direct' whenever two occurrents succeed one another directly. We may relabel this simply 'provides input for', as directness is implicit" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589         "directly provides input for (process to process)" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002328  a        owl:ObjectProperty ;
        rdfs:label       "functionally related to"@en ;
        obo:IAO_0000115  "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "This is a grouping relation that collects relations used for the purpose of connecting structure and function" .

obo:RO_0002202  a           owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:comment        "This is the transitive form of the develops from relation" ;
        rdfs:domain         obo:BFO_0000004 ;
        rdfs:label          "develops from"@en ;
        rdfs:range          obo:BFO_0000004 ;
        rdfs:subPropertyOf  obo:RO_0002258 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" ;
        obo:IAO_0000117     "Chris Mungall"@en , "David Osumi-Sutherland"@en , "Terry Meehan"@en , "Melissa Haendel" ;
        owl:inverseOf       obo:RO_0002203 .

:x      a       swrl:Variable .

obo:RO_0002509  a               owl:ObjectProperty ;
        rdfs:domain             obo:RO_0002577 ;
        rdfs:label              "determined by part of" ;
        rdfs:range              obo:BFO_0000040 ;
        rdfs:subPropertyOf      obo:RO_0002506 , obo:RO_0002131 ;
        obo:IAO_0000115         "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." ;
        obo:IAO_0000117         "Chris Mungall" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002570  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "conduit for" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:IAO_0000115     "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "UBERON:cjm" ;
        obo:IAO_0000232     "This relation holds between a thing with a 'conduit' (e.g. a bone foramen) and a 'conduee' (for example, a nerve) such that at the time the relationship holds, the conduee has two ends sticking out either end of the conduit. It should therefore note be used for objects that move through the conduit but whose spatial extent does not span the passage. For example, it would not be used for a mountain that contains a long tunnel through which trains pass. Nor would we use it for a digestive tract and objects such as food that pass through." ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002485  a           owl:ObjectProperty ;
        rdfs:label          "receives input from" ;
        rdfs:subPropertyOf  obo:RO_0002170 ;
        obo:IAO_0000116     "See notes for inverse relation" ;
        obo:IAO_0000117     "Chris Mungall" ;
        owl:inverseOf       obo:RO_0002486 .

obo:RO_0002093  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0009003  a        owl:ObjectProperty , owl:IrreflexiveProperty ;
        rdfs:domain      obo:BFO_0000040 ;
        rdfs:label       "immersed in"@en ;
        rdfs:range       obo:BFO_0000040 ;
        obo:IAO_0000112  "sardines 'immersed in' some 'oil and mustard'"@en ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "\"immersed in\" is a relation between a (physical) entity and a fluid substance in which the entity is wholely or substantially surrounded by the substance."@en ;
        obo:IAO_0000117  "Damion Dooley" .

obo:IAO_0000426  rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "An assertion that holds between an OWL Object Property and a string or literal, where the value of the string or literal is a Common Logic sentence of collection of sentences that define the Object Property." .

obo:RO_0004009  a                owl:ObjectProperty ;
        rdfs:label               "has primary input" ;
        rdfs:subPropertyOf       obo:RO_0004007 , obo:RO_0002233 ;
        obo:IAO_0000115          "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-12-13T11:26:56Z"^^xsd:dateTime .

obo:RO_0002540  a           owl:AnnotationProperty ;
        rdfs:label          "end, days post fertilization" ;
        rdfs:subPropertyOf  obo:RO_0002538 ;
        obo:IAO_0000115     "Count of number of days intervening between the end of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 1 for this property." .

obo:RO_0002455  a           owl:ObjectProperty ;
        rdfs:label          "pollinates" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/pollinates" ;
        rdfs:subPropertyOf  obo:RO_0002442 ;
        obo:IAO_0000112     "Bees pollinate Flowers" ;
        obo:IAO_0000116     "This relation is intended to be used for biotic pollination - e.g. a bee pollinating a flowering plant. Some kinds of pollination may be semibiotic - e.g. wind can have the role of pollinator. We would use a separate relation for this." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "is subject of pollination interaction with" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002456 .

obo:RO_0002244  a           owl:ObjectProperty ;
        rdfs:domain         obo:RO_0002310 ;
        rdfs:label          "related via exposure to" ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "Any relationship between an exposure event or process and any other entity." ;
        obo:IAO_0000232     "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes." .

obo:RO_0002636  a           owl:ObjectProperty ;
        rdfs:label          "mesoparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite" ;
        owl:inverseOf       obo:RO_0002637 .

obo:RO_0002159  a           owl:ObjectProperty , owl:TransitiveProperty , owl:SymmetricProperty ;
        rdfs:label          "serially homologous to" ;
        rdfs:subPropertyOf  obo:RO_0002320 ;
        obo:IAO_0000114     obo:IAO_0000125 .

obo:RO_0002510  a           owl:ObjectProperty ;
        rdfs:domain         []  ;
        rdfs:label          "transcribed from" ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002330 ;
        obo:IAO_0000115     "x is transcribed from y if and only if x is synthesized from template y" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        owl:inverseOf       obo:RO_0002511 .

obo:RO_0002425  a           owl:ObjectProperty ;
        rdfs:label          "differs in attribute of"@en ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002424 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002214  a        owl:ObjectProperty ;
        rdfs:domain      []  ;
        rdfs:label       "has prototype"@en ;
        obo:IAO_0000112  "'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))" , "heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')" ;
        obo:IAO_0000114  obo:IAO_0000125 ;
        obo:IAO_0000115  "x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a \"canonical\" heart, which participates in blood circulation." ;
        obo:IAO_0000116  "Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)" , "TODO: add homeomorphy axiom" , "This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants." ;
        obo:IAO_0000117  "Chris Mungall" .

obo:RO_0002606  a           owl:ObjectProperty ;
        rdfs:label          "is substance that treats" ;
        rdfs:seeAlso        <https://code.google.com/p/obo-relations/issues/detail?id=46> ;
        rdfs:subPropertyOf  obo:RO_0002599 ;
        obo:IAO_0000115     "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." ;
        obo:IAO_0000118     "treats" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> .

obo:RO_0004010  a                owl:ObjectProperty ;
        rdfs:label               "is genetic basis for condition" ;
        rdfs:range               obo:BFO_0000017 ;
        rdfs:subPropertyOf       obo:RO_0004018 ;
        obo:IAO_0000232          "Do not use this relation directly. It is intended as a grouping for a more specific relations" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:53:08Z"^^xsd:dateTime .

obo:RO_0002003  a              owl:ObjectProperty ;
        rdfs:label             "electrically_synapsed_to" ;
        rdfs:subPropertyOf     obo:RO_0000300 ;
        obo:IAO_0000115        "A relation that holds between two neurons that are electrically coupled via gap junctions." ;
        obo:IAO_0000117        "David Osumi-Sutherland" ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002582  a           owl:AnnotationProperty ;
        rdfs:label          "is a defining property chain axiom where second argument is reflexive" ;
        rdfs:subPropertyOf  obo:RO_0002581 ;
        obo:IAO_0000115     "If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R." .

oboInOwl1:creation_date
        a       owl:AnnotationProperty .

obo:RO_0002497  a               owl:ObjectProperty ;
        rdfs:comment            "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label              "existence ends during or before" ;
        rdfs:subPropertyOf      obo:RO_0002487 ;
        obo:IAO_0000115         "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002371  a           owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label          "attached to"@en ;
        rdfs:subPropertyOf  obo:RO_0002177 , obo:RO_0002170 ;
        obo:IAO_0000115     "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000589     "attached to (anatomical structure to anatomical structure)" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002286  a           owl:ObjectProperty ;
        rdfs:label          "developmentally succeeded by"@en ;
        rdfs:subPropertyOf  obo:RO_0002384 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Inverse of developmentally preceded by" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002160  a           owl:ObjectProperty ;
        rdfs:label          "only in taxon" ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002162 ;
        obo:IAO_0000112     "lactation SubClassOf 'only in taxon' some 'Mammalia'" ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." ;
        obo:IAO_0000116     "The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.\n\n 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria" ;
        obo:IAO_0000117     "Chris Mungall"@en ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20973947> , <http://www.ncbi.nlm.nih.gov/pubmed/17921072> .

obo:RO_0002552  a           owl:ObjectProperty ;
        rdfs:label          "results in ending of" ;
        rdfs:subPropertyOf  obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000115     "p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002467  a           owl:ObjectProperty ;
        rdfs:label          "is mutualism" ;
        rdfs:subPropertyOf  obo:RO_0002465 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0040042  a                owl:AnnotationProperty ;
        rdfs:comment             "R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C." ;
        rdfs:label               "is homeomorphic for" ;
        rdfs:seeAlso             <https://github.com/oborel/obo-relations/issues/164> ;
        rdfs:subPropertyOf       obo:RO_0002422 ;
        obo:IAO_0000112          "part-of is homeomorphic for independent continuants." ;
        obo:IAO_0000115          "R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-10-21T19:46:34Z"^^xsd:dateTime .

obo:RO_0002341  a           owl:ObjectProperty ;
        rdfs:label          "results in transport along"@en ;
        rdfs:subPropertyOf  obo:RO_0002337 ;
        obo:IAO_0000115     "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002256  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "developmentally induced by"@en ;
        rdfs:range          obo:CARO_0000003 ;
        rdfs:subPropertyOf  obo:RO_0002258 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T" ;
        obo:IAO_0000117     "Melissa Haendel" , "David Osumi-Sutherland" , "Chris Mungall" ;
        obo:IAO_0000118     "induced by" ;
        obo:IAO_0000119     " Developmental Biology, Gilbert, 8th edition, figure 6.5(F)" , "GO:0001759" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20064205> ;
        obo:IAO_0000232     "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" ;
        owl:inverseOf       obo:RO_0002257 .

obo:RO_0002130  a               owl:ObjectProperty ;
        rdfs:domain             []  ;
        rdfs:label              "has synaptic terminal in"@en ;
        rdfs:subPropertyOf      obo:RO_0002131 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." ;
        obo:IAO_0000117         "David Osumi-Sutherland"@en ;
        obo:IAO_0000118         "has synapse in" ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)" ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002522  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "bounds sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002514 ;
        obo:IAO_0000112        "The genomic exons of a transcript bound the sequence of the genomic introns of the same transcript (but the introns are not subsequences of the exons)" ;
        obo:IAO_0000115        "x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y" ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:inverseOf          obo:RO_0002523 .

obo:RO_0002437  a           owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "biotically interacts with" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:seeAlso        "http://eol.org/schema/terms/interactsWith" ;
        rdfs:seeAlso        <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
        rdfs:subPropertyOf  obo:RO_0002434 , obo:RO_0002321 ;
        obo:IAO_0000115     "An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "interacts with on organism level" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002226  a               owl:ObjectProperty ;
        rdfs:domain             obo:CARO_0000000 ;
        rdfs:label              "develops in"@en ;
        rdfs:subPropertyOf      obo:RO_0002258 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x develops_in y if x is located in y whilst x is developing" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         "Jonathan Bard, EHDAA2" , "EHDAA2" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002015  a                owl:ObjectProperty ;
        rdfs:comment             "By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'." ;
        rdfs:label               "has positive regulatory component activity" ;
        rdfs:subPropertyOf       obo:RO_0002013 , obo:RO_0002336 ;
        obo:IAO_0000115          "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:31:17Z"^^xsd:dateTime .

obo:RO_0002618  a           owl:ObjectProperty ;
        rdfs:label          "visits" ;
        rdfs:seeAlso        "https://github.com/oborel/obo-relations/issues/74"^^xsd:anyURI ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        owl:inverseOf       obo:RO_0002619 .

obo:RO_0002100  a               owl:ObjectProperty ;
        rdfs:domain             obo:CL_0000540 ;
        rdfs:label              "has soma location"@en ;
        rdfs:range              obo:CARO_0000003 ;
        rdfs:subPropertyOf      obo:RO_0002131 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a neuron and an anatomical structure that its soma is part of."@en ;
        obo:IAO_0000117         "David Osumi-Sutherland" ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/BFO_0000051> some (\n   <http://purl.obolibrary.org/obo/GO_0043025> and   <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)" ;
        obo:RO_0001900          obo:RO_0001901 ;
        owl:propertyChainAxiom  []  .

obo:RO_0004022  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease has basis in feature" ;
        rdfs:range               []  ;
        rdfs:subPropertyOf       obo:RO_0004019 , obo:RO_0002200 ;
        obo:IAO_0000115          "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:46:07Z"^^xsd:dateTime .

obo:RO_0002407  a               owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label              "indirectly activates"@en ;
        rdfs:subPropertyOf      obo:RO_0002213 ;
        obo:IAO_0000115         "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "indirectly positively regulates" ;
        obo:RO_0002579          obo:RO_0002213 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0008503  a           owl:ObjectProperty ;
        rdfs:label          "kleptoparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relation of parasite of in which a parasite steals resources from another organism, usually food or nest material" ;
        obo:IAO_0000119     "https://en.wikipedia.org/wiki/Kleptoparasitism" ;
        owl:inverseOf       obo:RO_0008504 .

obo:RO_0002594  a           owl:AnnotationProperty ;
        rdfs:label          "is relational form of a class" ;
        rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "An annotation property that connects an object property to a class, where the object property is derived from or a shortcut property for the class. The exact semantics of this annotation may vary on a case by case basis." .

obo:RO_0002383  a           owl:ObjectProperty ;
        rdfs:label          "proper tributary of"@en ;
        rdfs:subPropertyOf  obo:RO_0002376 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x proper_tributary_of y iff x tributary_of y and x does not originate from y" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002298  a            owl:ObjectProperty ;
        rdfs:label           "results in morphogenesis of"@en ;
        rdfs:subPropertyOf   obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000112      "an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape." , "tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723)"@en ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000115      "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000119      "GOC:mtg_berkeley_2013" ;
        oboInOwl1:shorthand  "results_in_morphogenesis_of" .

obo:RO_0010002  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000004 ;
        rdfs:label              "is carrier of"@en ;
        rdfs:range              obo:BFO_0000031 ;
        obo:IAO_0000112         "Molecules of DNA are carriers of genetic information." , "This copy of *War and Peace* is carrier of the novel written by Tolstoy." , "This hard drive is carrier of these data items." ;
        obo:IAO_0000115         "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" ;
        obo:IAO_0000119         "[072-ISO]" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002172  a           owl:AnnotationProperty ;
        rdfs:label          "taxonomic class assertion"@en ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002420 ;
        obo:IAO_0000115     "An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon." .

obo:RO_0002564  a           owl:ObjectProperty ;
        rdfs:label          "molecular interaction relation helper property" ;
        rdfs:subPropertyOf  obo:RO_0002563 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_HOM0000001  rdfs:subPropertyOf  obo:RO_0002158 .

obo:RO_0002087  owl:propertyChainAxiom  []  .

obo:RO_0002479  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000003 ;
        rdfs:label              "has part that occurs in" ;
        rdfs:range              obo:BFO_0000004 ;
        obo:IAO_0000115         "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." ;
        obo:IAO_0000117         "Chris Mungall" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002353  a           owl:ObjectProperty ;
        rdfs:label          "output of"@en ;
        rdfs:subPropertyOf  obo:RO_0000056 , obo:RO_0002328 ;
        obo:IAO_0000115     "inverse of has output" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

<urn:swrl#C>  a  swrl:Variable .

obo:RO_0002534  a        owl:Class ;
        rdfs:label       "sequence bearer" ;
        rdfs:subClassOf  obo:RO_0002532 ;
        obo:IAO_0000115  "Any entity that can be divided into parts such that each part is an atomical unit of a sequence" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Sequence bearers can be molecular entities, such as a portion of a DNA molecule, or they can be abstract entities, such as an entity representing all human sonic hedgehog regions of the genome with a particular DNA sequence." .

obo:RO_0002449  a                  owl:ObjectProperty ;
        rdfs:label                 "activity directly negatively regulates activity of" ;
        rdfs:subPropertyOf         obo:RO_0002448 ;
        obo:IAO_0000115            "Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000118            "inhibits" ;
        oboInOwl1:hasExactSynonym  "molecularly decreases activity of" ;
        owl:propertyChainAxiom     []  .

obo:RO_0002323  a        owl:ObjectProperty ;
        rdfs:label       "mereotopologically related to"@en ;
        obo:IAO_0000115  "A mereological relationship or a topological relationship" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" ;
        obo:RO_0001900   obo:RO_0001901 .

obo:RO_0002112  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type Is terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ;
        rdfs:label             "synapsed_by_via_type_Is_bouton"@en ;
        rdfs:subPropertyOf     obo:RO_0002103 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "Relation between a muscle and a motor neuron that synapses to it via a type Is bouton." ;
        obo:IAO_0000117        "David Osumi-Sutherland" , "Marta Costa" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061177 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002504  a           owl:AnnotationProperty ;
        rdfs:label          "always present in taxon" ;
        rdfs:subPropertyOf  obo:RO_0002175 ;
        obo:IAO_0000112     "forelimb always_present_in_taxon Euarchontoglires" , "brain always_present_in_taxon 'Vertebrata'" ;
        obo:IAO_0000115     "S always_present_in_taxon T if every fully formed member of taxon T has part some S, or is an instance of S" ;
        obo:IAO_0000116     "This is a very strong relation. Often we will not have enough evidence to know for sure that there are no species within a lineage that lack the structure - loss is common in evolution. However, there are some statements we can make with confidence - no vertebrate lineage could persist without a brain or a heart. All primates are limbed. " ;
        obo:IAO_0000118     "never lost in" .

obo:RO_0004034  a                owl:ObjectProperty ;
        rdfs:label               "acts upstream of, positive effect" ;
        rdfs:seeAlso             <http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect> ;
        rdfs:subPropertyOf       obo:RO_0002263 , obo:RO_0004032 ;
        obo:IAO_0000115          "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ;
        obo:RO_0004049           obo:RO_0002263 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-01-26T23:53:14Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002419  a           owl:AnnotationProperty ;
        rdfs:label          "annotation property cardinality"@en ;
        rdfs:range          xsd:nonNegativeInteger ;
        rdfs:subPropertyOf  obo:RO_0002423 ;
        obo:IAO_0000115     "An assertion that holds between an OWL Annotation Property P and a non-negative integer N, with the interpretation: for any P(i j) it must be the case that | { k : P(i k) } | = N." .

obo:RO_0002480  a               owl:ObjectProperty ;
        rdfs:label              "ubiquitinates" ;
        rdfs:subPropertyOf      obo:RO_0002436 ;
        obo:IAO_0000115         "An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y" ;
        obo:IAO_0000116         "Axiomatization to GO to be added later" ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002208  a           owl:ObjectProperty ;
        rdfs:label          "parasitoid of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A parasite that kills or sterilizes its host" ;
        owl:inverseOf       obo:RO_0002209 .

obo:RO_0004004  a                owl:ObjectProperty ;
        rdfs:label               "has material basis in somatic mutation in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317344> ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:46:07Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004014 .

obo:RO_0002576  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "skeleton of" ;
        rdfs:range          obo:CARO_0000003 ;
        rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000115     "inverse of has skeleton" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002450  a                  owl:ObjectProperty ;
        rdfs:label                 "activity directly positively regulates activity of" ;
        rdfs:subPropertyOf         obo:RO_0002448 ;
        obo:IAO_0000115            "Holds between molecular entities A and B where A can physically interact with B and in doing so positively regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000118            "activates" ;
        oboInOwl1:hasExactSynonym  "molecularly increases activity of" ;
        owl:propertyChainAxiom     []  .

obo:RO_0002546  a           owl:AnnotationProperty ;
        rdfs:label          "has developmental stage marker" ;
        rdfs:subPropertyOf  obo:RO_0002535 ;
        obo:IAO_0000115     "A relationship between a stage class and an anatomical structure or developmental process class, in which the stage is characterized by the appearance of the structure or the occurrence of the biological process" .

obo:RO_0002420  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion on a class"@en ;
        rdfs:subPropertyOf  obo:RO_0002416 ;
        obo:IAO_0000115     "A logical macro assertion whose domain is an IRI for a class" ;
        obo:IAO_0000116     "The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL" .

obo:RO_0040036  a                owl:ObjectProperty ;
        rdfs:label               "has anatomical participant" ;
        rdfs:range               []  ;
        rdfs:subPropertyOf       obo:RO_0000057 ;
        obo:IAO_0000115          "p has anatomical participant c iff p has participant c, and c is an anatomical entity" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-09-26T01:08:58Z"^^xsd:dateTime .

obo:RO_0002335  a           owl:ObjectProperty ;
        rdfs:label          "negatively regulated by"@en ;
        rdfs:subPropertyOf  obo:RO_0002334 ;
        obo:IAO_0000115     "inverse of negatively regulates" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002601  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion involving identity" ;
        rdfs:subPropertyOf  obo:RO_0002416 ;
        obo:IAO_0000115     "A shortcut relationship that holds between two entities based on their identity criteria" .

obo:IAO_0000589  a  owl:AnnotationProperty .

obo:RO_0002516  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "has start sequence" ;
        rdfs:subPropertyOf     obo:RO_0002524 ;
        obo:IAO_0000112        "Every CDS has as a start sequence the start codon for that transcript" ;
        obo:IAO_0000115        "x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "started by" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:inverseOf          obo:RO_0002517 .

obo:RO_0004046  a                owl:ObjectProperty ;
        rdfs:label               "causally upstream of or within, negative effect" ;
        rdfs:subPropertyOf       obo:RO_0002418 ;
        obo:RO_0004050           obo:RO_0002418 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-03-13T23:55:05Z"^^xsd:dateTime .

obo:RO_0002492  a               owl:ObjectProperty ;
        rdfs:comment            "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label              "existence ends during" ;
        rdfs:subPropertyOf      obo:RO_0002497 , obo:RO_0002490 ;
        obo:IAO_0000115         "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

subsets:ro-eco  a           owl:AnnotationProperty ;
        rdfs:label          "eco subset" ;
        rdfs:subPropertyOf  oboInOwl1:SubsetProperty .

obo:RO_0002305  a           owl:ObjectProperty ;
        rdfs:comment        "holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y" ;
        rdfs:label          "causally upstream of, negative effect" ;
        rdfs:subPropertyOf  obo:RO_0002411 , obo:RO_0004046 ;
        obo:RO_0004050      obo:RO_0002411 ;
        dc:creator          "cjm" .

obo:RO_0003306  a           owl:ObjectProperty ;
        rdfs:label          "contributes to frequency of condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003304 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ;
        obo:IAO_0000118     "contributes to penetrance of condition" .

obo:RO_0002009  a           owl:ObjectProperty ;
        rdfs:domain         obo:CL_0000000 ;
        rdfs:label          "cell expresses" ;
        rdfs:subPropertyOf  obo:RO_0002292 ;
        obo:IAO_0000115     "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        dc:description      "x 'cell expresses' y iff:\ncell(x)\nAND gene(y)\nAND exists some 'transcription, DNA templated (GO_0006351)'(t)\nAND t occurs_in x\nAND t has_input y" .

obo:RO_0004016  a                owl:ObjectProperty ;
        rdfs:label               "is causal germline mutation partially giving rise to" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317346> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:58:43Z"^^xsd:dateTime .

<urn:swrl#z>  a  swrl:Variable .

obo:RO_0002588  a           owl:ObjectProperty ;
        rdfs:label          "results in assembly of" ;
        rdfs:subPropertyOf  obo:RO_0002297 , obo:RO_0002592 .

obo:RO_0002462  a           owl:ObjectProperty ;
        rdfs:label          "subject participant in" ;
        rdfs:subPropertyOf  obo:RO_0002461 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Experimental: relation used for defining interaction relations; the meaning of s 'subject participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the subject is the predator. We can imagine a reciprocal prey-predatory process with subject and object reversed." .

obo:RO_0002377  a           owl:ObjectProperty ;
        rdfs:comment        "This is both a mereotopological relationship and a relationship defined in connection to processes. It concerns both the connecting structure, and how this structure is disposed to causally affect flow processes" ;
        rdfs:label          "distributary of"@en ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000112     "Deschutes River distributary_of Little Lava Lake" ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "distributary channel of" , "branch of" ;
        obo:IAO_0000119     "http://en.wikipedia.org/wiki/Distributary" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002558  a           owl:ObjectProperty ;
        rdfs:comment        "x has evidence y iff , x is  an information content entity, material entity or process, and y supports either the existence of x, or the truth value of x." ;
        rdfs:label          "has evidence" ;
        rdfs:subPropertyOf  obo:RO_0002616 ;
        obo:IAO_0000115     "inverse of is evidence for" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/25052702> ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002432  a                  owl:ObjectProperty ;
        rdfs:comment               "" ;
        rdfs:label                 "is active in" ;
        rdfs:subPropertyOf         obo:RO_0002131 , obo:RO_0002328 ;
        obo:IAO_0000112            "A protein that enables activity in a cytosol." ;
        obo:IAO_0000115            "c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000118            "executes activity in" ;
        oboInOwl1:hasExactSynonym  "enables activity in" ;
        owl:propertyChainAxiom     []  .

obo:RO_0002221  a           owl:ObjectProperty ;
        rdfs:label          "surrounds"@en ;
        rdfs:subPropertyOf  obo:RO_0002220 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of surrounded by" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002613  a           owl:AnnotationProperty ;
        rdfs:label          "axiom contradicted by evidence" ;
        rdfs:subPropertyOf  obo:RO_0002611 ;
        obo:IAO_0000115     "A relationship between a sentence and an instance of a piece of evidence in which the evidence contradicts the axiom" ;
        obo:IAO_0000232     "This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual." .

obo:RO_0002528  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "is upstream of sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002527 ;
        obo:IAO_0000115        "inverse of downstream of sequence of" ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:BFO_0000050  a          owl:ObjectProperty ;
        rdfs:seeAlso        <http://ontologydesignpatterns.org/wiki/Submissions:PartOf> , <http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections> ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:RO_0040042      obo:BFO_0000019 , obo:BFO_0000004 , obo:BFO_0000017 , obo:BFO_0000003 , obo:BFO_0000020 , obo:BFO_0000002 , obo:BFO_0000031 .

obo:RO_0002010  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000015 ;
        rdfs:label          "regulates in other organism" ;
        rdfs:range          obo:BFO_0000015 ;
        rdfs:subPropertyOf  obo:RO_0002418 ;
        obo:IAO_0000115     "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." ;
        obo:IAO_0000117     "David Osumi-Sutherland" .

obo:RO_0002402  a        owl:ObjectProperty ;
        rdfs:label       "obsolete has direct output" ;
        obo:IAO_0000112  "translation SubClassOf has_direct_output some protein" ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. " ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000118  "directly produces" ;
        owl:deprecated   true .

owl:topObjectProperty
        a       owl:ObjectProperty .

obo:RO_0002293  a           owl:ObjectProperty ;
        rdfs:label          "ubiquitously expresses"@en ;
        rdfs:subPropertyOf  obo:RO_0002292 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of ubiquiotously expressed in" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002106  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('type Is terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ;
        rdfs:label             "synapsed_via_type_Is_bouton_to"@en ;
        rdfs:subPropertyOf     obo:RO_0002120 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "A relation between a motor neuron and a muscle that it synapses to via a type Is bouton." ;
        obo:IAO_0000117        "Marta Costa" , "David Osumi-Sutherland" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0061177 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf          obo:RO_0002112 .

obo:RO_0004028  a                owl:ObjectProperty ;
        rdfs:domain              obo:BFO_0000017 ;
        rdfs:label               "realized in response to stimulus" ;
        rdfs:range               obo:BFO_0000040 ;
        rdfs:subPropertyOf       obo:RO_0002410 ;
        obo:IAO_0000115          "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-12-26T19:45:49Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002082  obo:IAO_0000117  "David Osumi-Sutherland" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002474  a           owl:AnnotationProperty ;
        rdfs:label          "dispositional interpretation" ;
        rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "An assertion that holds between an OWL Object Property and a dispositional interpretation that elucidates how OWL Class Axioms or OWL Individuals that use this property are to be interpreted in a dispositional context. For example,  A binds B may be interpreted as A have a mutual disposition that is realized by binding to the other one." .

obo:RO_0002263  a               owl:ObjectProperty ;
        rdfs:label              "acts upstream of" ;
        rdfs:seeAlso            <http://wiki.geneontology.org/index.php/Acts_upstream_of> ;
        rdfs:subPropertyOf      obo:RO_0002264 ;
        obo:IAO_0000112         "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." ;
        obo:IAO_0000115         "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ;
        owl:propertyChainAxiom  []  .

obo:RO_0002178  a           owl:ObjectProperty ;
        rdfs:label          "supplies"@en ;
        rdfs:subPropertyOf  obo:RO_0002170 ;
        obo:IAO_0000115     "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." ;
        obo:IAO_0000116     "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20064205> .

obo:RO_0002444  a                  owl:ObjectProperty ;
        rdfs:label                 "parasite of" ;
        rdfs:seeAlso               "http://eol.org/schema/terms/parasitizes" ;
        rdfs:subPropertyOf         obo:RO_0002454 , obo:RO_0002443 ;
        obo:IAO_0000112            "Pediculus humanus capitis parasite of human" ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000118            "parasitizes" ;
        obo:RO_0002560             obo:GO_0072519 ;
        oboInOwl1:hasExactSynonym  "direct parasite of" ;
        oboInOwl1:inSubset         subsets:ro-eco ;
        owl:inverseOf              obo:RO_0002445 ;
        owl:propertyChainAxiom     []  .

foaf:page  a    owl:AnnotationProperty .

obo:RO_0002233  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000015 ;
        rdfs:label              "has input"@en ;
        rdfs:range              obo:BFO_0000040 ;
        rdfs:subPropertyOf      obo:RO_0000057 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "consumes" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:inverseOf           obo:RO_0002352 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002625  a           owl:ObjectProperty ;
        rdfs:label          "has eggs laid in by" ;
        rdfs:subPropertyOf  obo:RO_0002445 , obo:RO_0002619 .

obo:RO_0001021  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "is autoimmune trigger for"@en ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000115     "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
        owl:inverseOf       obo:RO_0001023 .

obo:BFO_0000062  oboInOwl1:inSubset  subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002022  a                owl:ObjectProperty ;
        rdfs:comment             "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
        rdfs:label               "directly regulated by" ;
        rdfs:subPropertyOf       obo:RO_0002334 ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-09-17T13:52:24Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0002578 .

obo:RO_0002414  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:domain         obo:BFO_0000015 ;
        rdfs:label          "transitively provides input for"@en ;
        rdfs:range          obo:BFO_0000015 ;
        rdfs:subPropertyOf  obo:RO_0002411 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "transitive form of directly_provides_input_for" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "This is a grouping relation that should probably not be used in annotation. Consider instead the child relation 'directly provides input for' (which may later be relabeled simply to 'provides input for')" ;
        obo:IAO_0000589     "transitively provides input for (process to process)" .

obo:RO_0002329  a               owl:ObjectProperty ;
        rdfs:label              "part of structure that is capable of"@en ;
        rdfs:subPropertyOf      obo:RO_0002328 ;
        obo:IAO_0000115         "this relation holds between c and p when c is part of some c', and c' is capable of p." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         false ;
        owl:propertyChainAxiom  []  .

obo:RO_0002203  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "develops into"@en ;
        rdfs:subPropertyOf  obo:RO_0002387 , obo:RO_0002388 , obo:RO_0002286 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of develops from" ;
        obo:IAO_0000117     "Terry Meehan"@en , "David Osumi-Sutherland"@en , "Chris Mungall"@en ;
        oboInOwl1:inSubset  obo:RO_0002259 .

:y      a       swrl:Variable .

obo:RO_0000092  obo:IAO_0000115  "inverse of has disposition" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002571  a           owl:ObjectProperty ;
        rdfs:label          "lumen of" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000115     "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "GOC:cjm" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002486  a           owl:ObjectProperty ;
        rdfs:label          "sends output to" ;
        rdfs:subPropertyOf  obo:RO_0002170 ;
        obo:IAO_0000116     "This is an exploratory relation. The label is taken from the FMA. It needs aligned with the neuron-specific relations such as has postsynaptic terminal in." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002360  a           owl:ObjectProperty ;
        rdfs:label          "has dendrite location"@en ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:IAO_0000117     "Chris Mungall" ;
        dc:source           "http://neurolex.org/wiki/Property:DendriteLocation"^^xsd:anyURI .

<urn:swrl#eff>  a  swrl:Variable .

obo:BFO_0000002  rdfs:subClassOf  []  ;
        rdfs:subClassOf  []  .

obo:RO_0002541  a           owl:AnnotationProperty ;
        rdfs:label          "start, years post birth" ;
        rdfs:subPropertyOf  obo:RO_0002537 ;
        obo:IAO_0000115     "Count of number of years intervening between the start of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 0 for this property, and the period during which the child is one year old has the value 1." .

obo:RO_0002456  a           owl:ObjectProperty ;
        rdfs:label          "pollinated by" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/hasPollinator" ;
        rdfs:subPropertyOf  obo:RO_0002442 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "is target of pollination interaction with" , "has polinator" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002330  a        owl:ObjectProperty ;
        rdfs:domain      obo:BFO_0000002 ;
        rdfs:label       "genomically related to"@en ;
        rdfs:range       obo:BFO_0000002 ;
        obo:IAO_0000115  "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism" .

obo:RO_0002245  a           owl:ObjectProperty ;
        rdfs:label          "over-expressed in" ;
        rdfs:subPropertyOf  obo:RO_0002206 ;
        obo:IAO_0000115     "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." .

obo:RO_0002637  a           owl:ObjectProperty ;
        rdfs:label          "has mesoparasite" ;
        rdfs:subPropertyOf  obo:RO_0002445 ;
        obo:IAO_0000115     "inverse of mesoparasite of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002511  a           owl:ObjectProperty ;
        rdfs:label          "transcribed to" ;
        rdfs:subPropertyOf  obo:RO_0002330 ;
        obo:IAO_0000115     "inverse of transcribed from" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002426  a           owl:ObjectProperty ;
        rdfs:label          "differs in attribute"@en ;
        rdfs:range          obo:BFO_0000020 ;
        rdfs:subPropertyOf  obo:RO_0002424 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002300  a            owl:ObjectProperty ;
        rdfs:label           "results in disappearance of"@en ;
        rdfs:subPropertyOf   obo:RO_0002552 ;
        obo:IAO_0000112      "foramen ovale closure SubClassOf results in disappearance of foramen ovale" ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000232      "May be merged into parent relation" ;
        oboInOwl1:shorthand  "results_in_disappearance_of" .

obo:RO_0003301  a        owl:ObjectProperty , owl:AsymmetricProperty , owl:IrreflexiveProperty ;
        rdfs:comment     "The driving use case for this relation was to link a biological model system such as a cell line or model organism to a disease it is used to investigate, in virtue of the model system exhibiting features similar to that of the disease of interest." ;
        rdfs:label       "is model of"@en ;
        obo:IAO_0000115  "Relation between a research artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity." ;
        obo:IAO_0000116  "To Do: decide on scope of this relation - inclusive of computational models in domain, or only physical models?  Restricted to linking biological systems and phenomena?  Inclusive of only diseases in range, or broader?" ;
        obo:IAO_0000117  "Matthew Brush" .

obo:RO_0002215  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000004 ;
        rdfs:label              "capable of"@en ;
        rdfs:range              obo:BFO_0000015 ;
        rdfs:subPropertyOf      obo:RO_0002216 ;
        obo:IAO_0000112         "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" , "osteoclast SubClassOf 'capable of' some 'bone resorption'" ;
        obo:IAO_0000115         "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "has function realized in" ;
        obo:IAO_0000119         <http://www.ncbi.nlm.nih.gov/pubmed/20123131> , <http://www.ncbi.nlm.nih.gov/pubmed/21208450> ;
        obo:IAO_0000232         "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." ;
        obo:IAO_0000424         "RO_0000053 some (RO_0000054 only ?Y)" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002607  a           owl:ObjectProperty ;
        rdfs:label          "is marker for" ;
        rdfs:subPropertyOf  obo:RO_0002610 ;
        obo:IAO_0000115     "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." ;
        obo:IAO_0000116     "May be ceded to OBI" .

obo:RO_0004011  a                owl:ObjectProperty ;
        rdfs:label               "is causal gain of function germline mutation of in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_410296> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:55:51Z"^^xsd:dateTime .

obo:RO_0002004  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "tracheates"@en ;
        rdfs:range          obo:CARO_0000003 ;
        rdfs:subPropertyOf  obo:RO_0001018 ;
        obo:IAO_0000115     "The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to)." ;
        obo:IAO_0000117     "David Osumi-Sutherland" .

obo:RO_0002583  a           owl:ObjectProperty ;
        rdfs:label          "existence starts at point" ;
        rdfs:subPropertyOf  obo:RO_0002487 ;
        obo:IAO_0000115     "x existence starts at point y if and only if the time point at which x starts is equivalent to the time point at which y ends." .

obo:RO_0002372  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "has muscle origin"@en ;
        rdfs:seeAlso        <http://dbpedia.org/property/origin> ;
        rdfs:subPropertyOf  obo:RO_0002567 , obo:RO_0002371 ;
        obo:IAO_0000115     "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to."@en ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "Wikipedia:Insertion_(anatomy)"@en .

obo:RO_0002287  a               owl:ObjectProperty ;
        rdfs:label              "part of developmental precursor of"@en ;
        rdfs:subPropertyOf      obo:RO_0002286 ;
        obo:IAO_0000112         "'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue" ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002161  a           owl:AnnotationProperty ;
        rdfs:label          "never in taxon" ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002172 ;
        obo:IAO_0000112     "tooth SubClassOf 'never in taxon' value 'Aves'" ;
        obo:IAO_0000115     "x never in taxon T if and only if T is a class, and x does not instantiate the class expression \"in taxon some T\". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL." ;
        obo:IAO_0000117     "Chris Mungall"@en ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20973947> , <http://www.ncbi.nlm.nih.gov/pubmed/17921072> ;
        obo:IAO_0000425     "?X DisjointWith RO_0002162 some ?Y " .

obo:RO_0002553  a                    owl:ObjectProperty ;
        rdfs:label                   "hyperparasite of" ;
        rdfs:subPropertyOf           obo:RO_0002454 ;
        obo:IAO_0000115              "x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y" ;
        obo:IAO_0000116              "Note that parasite-of is a diret relationship, so hyperparasite-of is not considered a sub-relation, even though hyperparasitism can be considered a form of parasitism" ;
        obo:IAO_0000117              "Chris Mungall" ;
        obo:IAO_0000119              "https://en.wikipedia.org/wiki/Hyperparasite" , "http://eol.org/schema/terms/hyperparasitoidOf" ;
        oboInOwl1:hasRelatedSynonym  "epiparasite of" , "hyperparasitoid of" ;
        oboInOwl1:inSubset           subsets:ro-eco ;
        owl:inverseOf                obo:RO_0002554 ;
        owl:propertyChainAxiom       []  .

obo:RO_0002468  a           owl:ObjectProperty ;
        rdfs:label          "is parasitism" ;
        rdfs:subPropertyOf  obo:RO_0002465 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002342  a           owl:ObjectProperty ;
        rdfs:label          "results in transport across"@en ;
        rdfs:subPropertyOf  obo:RO_0002021 , obo:RO_0002344 ;
        obo:IAO_0000115     "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:GO_0044403  rdfs:subClassOf  []  .

obo:RO_0002257  a           owl:ObjectProperty ;
        rdfs:label          "developmentally induces"@en ;
        rdfs:subPropertyOf  obo:RO_0002386 , obo:RO_0002286 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Inverse of developmentally induced by"@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002131  a               owl:ObjectProperty ;
        rdfs:label              "overlaps"@en ;
        rdfs:subPropertyOf      obo:RO_0002323 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
        obo:IAO_0000424         "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" ;
        obo:RO_0001900          obo:RO_0001901 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002523  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "is bound by sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002514 ;
        obo:IAO_0000115        "inverse of bounds sequence of" ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        oboInOwl1:inSubset     obo:RO_0002259 .

obo:RO_0002438  a           owl:ObjectProperty ;
        rdfs:label          "trophically interacts with" ;
        rdfs:seeAlso        <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        obo:IAO_0000115     "An interaction relationship in which the partners are related via a feeding relationship." ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002312  a           owl:ObjectProperty ;
        rdfs:label          "evolutionary variant of"@en ;
        rdfs:subPropertyOf  obo:RO_0002320 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0004023  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "causal relationship with disease as subject" ;
        rdfs:subPropertyOf       obo:RO_0002410 , obo:RO_0040035 ;
        obo:IAO_0000232          "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:50:54Z"^^xsd:dateTime .

obo:RO_0002227  a           owl:ObjectProperty ;
        rdfs:label          "obligate parasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relation of parasite-of in which the parasite that cannot complete its life cycle without a host." .

obo:RO_0002619  a           owl:ObjectProperty ;
        rdfs:label          "visited by" ;
        rdfs:subPropertyOf  obo:RO_0002574 .

obo:RO_0002101  a              owl:ObjectProperty ;
        rdfs:domain            []  ;
        rdfs:label             "fasciculates with"@en ;
        rdfs:range             obo:CARO_0001001 ;
        rdfs:subPropertyOf     obo:RO_0002131 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"@en ;
        obo:IAO_0000117        "David Osumi-Sutherland" ;
        obo:IAO_0000118        "fasciculates with" ;
        obo:IAO_0000426        "(forall (?x ?y) \n\t(iff \n\t\t(fasciculates_with ?x ?y)\n\t\t(exists (?nps ?npbs)\n\t\t\t(and \n\t\t\t\t(\"neuron ; CL_0000540\" ?x)\n\t\t\t\t(\"neuron projection bundle ; CARO_0001001\" ?y) \n\t\t\t\t(\"neuron projection segment ; CARO_0001502\" ?nps)\n\t\t\t\t(\"neuron projection bundle segment ; CARO_0001500' \" ?npbs)\n\t\t\t\t(part_of ?npbs ?y) \t\t\t\n\t\t\t\t(part_of ?nps ?x)\n\t\t\t\t(part_of ?nps ?npbs)\n\t\t\t\t(forall (?npbss)\n\t\t\t\t\t(if\n\t\t\t\t\t\t(and \n\t\t\t\t\t\t\t(\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss)\n\t\t\t\t\t\t\t(part_of ?npbss ?npbs) \n\t\t\t\t\t\t)\n\t\t\t\t\t\t(overlaps ?nps ?npbss)\n\t\t\t\t\t))))))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf          obo:RO_0002132 .

obo:RO_0002595  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "causal relation between material entity and a process" ;
        rdfs:range          obo:BFO_0000015 ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
        obo:IAO_0000116     "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> .

obo:RO_0002408  a           owl:ObjectProperty ;
        rdfs:label          "directly inhibits"@en ;
        rdfs:subPropertyOf  obo:RO_0002630 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "directly negatively regulates" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "directly inhibits (process to process)" .

obo:RO_0002016  a                owl:ObjectProperty ;
        rdfs:comment             "A has necessary component activity B if A and B are GO molecular functions  (GO_0003674), A has_component B and B is necessary for A.  For example,  ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity." ;
        rdfs:label               "has necessary component activity" ;
        rdfs:subPropertyOf       obo:RO_0002017 , obo:RO_0002336 ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:36:08Z"^^xsd:dateTime .

obo:RO_0008504  a           owl:ObjectProperty ;
        rdfs:label          "kleptoparasitized by" ;
        rdfs:subPropertyOf  obo:RO_0002445 ;
        obo:IAO_0000115     "inverse of kleptoparasite of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002384  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000000 ;
        rdfs:label          "has developmental potential involving"@en ;
        rdfs:range          obo:CARO_0000000 ;
        rdfs:subPropertyOf  obo:RO_0002324 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)."@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:GO_0072519  rdfs:subClassOf  []  .

obo:RO_0002299  a            owl:ObjectProperty ;
        rdfs:label           "results in maturation of"@en ;
        rdfs:subPropertyOf   obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000112      " an annotation of gene X to cell maturation with results_in_maturation_of CL:0000057 (fibroblast) means that the fibroblast is mature at the end of the process" , "bone maturation (GO:0070977) results_in_maturation_of bone (UBERON:0001474)"@en ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000115      "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000119      "GOC:mtg_berkeley_2013" ;
        oboInOwl1:shorthand  "results_in_maturation_of" .

obo:RO_0002173  a           owl:AnnotationProperty ;
        rdfs:label          "ambiguous for taxon"@en ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002172 ;
        obo:IAO_0000115     "S ambiguous_for_taxon T if the class S does not have a clear referent in taxon T. An example would be the class 'manual digit 1', which encompasses a homology hypotheses that is accepted for some species (e.g. human and mouse), but does not have a clear referent in Aves - the referent is dependent on the hypothesis embraced, and also on the ontogenetic stage.  [PHENOSCPAE:asilomar_mtg]" .

obo:RO_0002565  a           owl:ObjectProperty ;
        rdfs:label          "results in movement of" ;
        rdfs:subPropertyOf  obo:RO_0040036 ;
        obo:IAO_0000115     "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "" .

obo:RO_0002088  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002354  a           owl:ObjectProperty ;
        rdfs:label          "formed as result of"@en ;
        rdfs:subPropertyOf  obo:RO_0002353 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002535  a           owl:AnnotationProperty ;
        rdfs:label          "temporal logical macro assertion on a class" ;
        rdfs:subPropertyOf  obo:RO_0002420 ;
        obo:IAO_0000232     "This properties were created originally for the annotation of developmental or life cycle stages, such as for example Carnegie Stage 20 in humans. " .

<urn:swrl#D>  a  swrl:Variable .

obo:RO_0002324  a        owl:ObjectProperty ;
        rdfs:label       "developmentally related to"@en ;
        obo:IAO_0000115  "A relationship that holds between entities participating in some developmental process (GO:0032502)" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" .

obo:RO_0002113  a               owl:ObjectProperty ;
        rdfs:domain             []  ;
        rdfs:label              "has presynaptic terminal in"@en ;
        rdfs:subPropertyOf      obo:RO_0002130 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."@en ;
        obo:IAO_0000118         "synapses in"@en ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)"@en ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002505  a           owl:ObjectProperty ;
        rdfs:label          "has intermediate" ;
        rdfs:subPropertyOf  obo:RO_0000057 ;
        obo:IAO_0000112     "'lysine biosynthetic process via diaminopimelate' SubClassOf has_intermediate some diaminopimelate" ;
        obo:IAO_0000115     "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "has intermediate product" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0004035  a                owl:ObjectProperty ;
        rdfs:label               "acts upstream of, negative effect" ;
        rdfs:seeAlso             <http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect> ;
        rdfs:subPropertyOf       obo:RO_0002263 , obo:RO_0004033 ;
        obo:IAO_0000115          "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ;
        obo:RO_0004050           obo:RO_0002263 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-01-26T23:53:22Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002481  a           owl:ObjectProperty ;
        rdfs:label          "is kinase activity" ;
        rdfs:subPropertyOf  obo:RO_0002564 ;
        obo:IAO_0000117     "Chris Mungall" .

rdfs:isDefinedBy  obo:IAO_0000589  "is defined by" .

obo:RO_0002209  a           owl:ObjectProperty ;
        rdfs:label          "has parasitoid" ;
        rdfs:subPropertyOf  obo:RO_0002445 ;
        obo:IAO_0000115     "inverse of parasitoid of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0004005  a                owl:ObjectProperty ;
        rdfs:label               "has major susceptibility factor" ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:46:26Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004015 .

obo:RO_0002577  rdfs:label  "system" ;
        rdfs:subClassOf  obo:BFO_0000040 ;
        obo:IAO_0000115  "A material entity consisting of multiple components that are causally integrated." ;
        obo:IAO_0000116  "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000119  "http://www.jbiomedsem.com/content/4/1/43" .

obo:RO_0002451  a           owl:ObjectProperty ;
        rdfs:label          "transmitted by" ;
        rdfs:subPropertyOf  obo:RO_0002321 ;
        obo:IAO_0000112     "all dengue disease transmitted by some mosquito" ;
        obo:IAO_0000115     "A relationship that holds between a disease and organism" ;
        obo:IAO_0000116     "Add domain and range constraints" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002240  a           owl:ObjectProperty ;
        rdfs:label          "has exposure receptor" ;
        rdfs:subPropertyOf  obo:RO_0002244 ;
        obo:IAO_0000115     "A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event." ;
        obo:IAO_0000119     "ExO:0000001" .

obo:RO_0002632  a           owl:ObjectProperty ;
        rdfs:label          "ectoparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host" ;
        obo:IAO_0000119     <https://en.wikipedia.org/wiki/Parasitism#Types> ;
        owl:inverseOf       obo:RO_0002633 .

<urn:swrl#mf2>  a  swrl:Variable .

obo:RO_0002547  a           owl:AnnotationProperty ;
        rdfs:label          "start, days post coitum" ;
        rdfs:subPropertyOf  obo:RO_0002537 ;
        obo:IAO_0000115     "Count of number of days intervening between the start of the stage and the time of coitum." ;
        obo:IAO_0000232     "For mouse staging: assuming that it takes place around midnight during a 7pm to 5am dark cycle (noon of the day on which the vaginal plug is found, the embryos are aged 0.5 days post coitum)" .

obo:RO_0002421  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion on a property"@en ;
        rdfs:subPropertyOf  obo:RO_0002416 ;
        obo:IAO_0000115     "A logical macro assertion whose domain is an IRI for a property" .

<urn:swrl#g1>  a  swrl:Variable .

obo:RO_0002336  a           owl:ObjectProperty ;
        rdfs:label          "positively regulated by"@en ;
        rdfs:subPropertyOf  obo:RO_0002334 ;
        obo:IAO_0000115     "inverse of positively regulates" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002210  a           owl:ObjectProperty ;
        rdfs:label          "directly develops into"@en ;
        rdfs:subPropertyOf  obo:RO_0002203 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of directly develops from" ;
        obo:IAO_0000118     "developmental precursor of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002602  a           owl:AnnotationProperty ;
        rdfs:label          "in approximate one to one relationship with" ;
        rdfs:subPropertyOf  obo:RO_0002601 ;
        obo:IAO_0000115     "A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds." .

<urn:swrl#p>  a  swrl:Variable .

obo:RO_0002517  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "is start sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002525 ;
        obo:IAO_0000115        "inverse of has start sequence" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "starts" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        oboInOwl1:inSubset     obo:RO_0002259 .

obo:RO_0004047  a                owl:ObjectProperty ;
        rdfs:label               "causally upstream of or within, positive effect" ;
        rdfs:subPropertyOf       obo:RO_0002418 ;
        obo:RO_0004049           obo:RO_0002418 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-03-13T23:55:19Z"^^xsd:dateTime .

obo:RO_0003000  a               owl:ObjectProperty ;
        rdfs:comment            "Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue." ;
        rdfs:domain             obo:BFO_0000040 ;
        rdfs:label              "produces"@en ;
        rdfs:range              obo:BFO_0000040 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." ;
        obo:IAO_0000117         "Melissa Haendel" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:inverseOf           obo:RO_0003001 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002493  a           owl:ObjectProperty ;
        rdfs:comment        "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label          "existence ends with" ;
        rdfs:subPropertyOf  obo:RO_0002492 ;
        obo:IAO_0000115     "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0003307  a           owl:ObjectProperty ;
        rdfs:comment        "Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. \n\nEnvironmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions." ;
        rdfs:label          "ameliorates condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003305 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
        obo:IAO_0000118     "is preventative for condition" .

obo:RO_0004017  a                owl:ObjectProperty ;
        rdfs:label               "realizable has basis in" ;
        rdfs:subPropertyOf       obo:RO_0002410 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:20:01Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004018 .

<urn:swrl#a1>  a  swrl:Variable .

obo:RO_0002589  a           owl:ObjectProperty ;
        rdfs:label          "results in catabolism of" ;
        rdfs:subPropertyOf  obo:RO_0002586 ;
        obo:IAO_0000115     "p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released." .

obo:RO_0002463  a           owl:ObjectProperty ;
        rdfs:label          "target participant in" ;
        rdfs:subPropertyOf  obo:RO_0002461 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Experimental: relation used for defining interaction relations; the meaning of s 'target participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the target is the prey. We can imagine a reciprocal prey-predatory process with subject and object reversed." .

obo:RO_0002378  a                 owl:ObjectProperty ;
        rdfs:label                "anabranch of"@en ;
        rdfs:subPropertyOf        obo:RO_0002377 ;
        rdfs:subPropertyOf        []  ;
        obo:IAO_0000114           obo:IAO_0000428 ;
        obo:IAO_0000115           "x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y." ;
        obo:IAO_0000117           "Chris Mungall" ;
        obo:IAO_0000118           "anastomoses with" ;
        oboInOwl1:inSubset        subsets:ro-eco ;
        owl:propertyDisjointWith  obo:RO_0002383 , obo:RO_0002382 .

obo:RO_0002252  a           owl:ObjectProperty ;
        rdfs:label          "connecting branch of" ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000115     "b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t." ;
        owl:inverseOf       obo:RO_0002253 .

obo:RO_0002559  a           owl:ObjectProperty ;
        rdfs:label          "causally influenced by" ;
        rdfs:subPropertyOf  obo:RO_0002506 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "causally influenced by (material entity to material entity)" ;
        owl:inverseOf       obo:RO_0002566 .

obo:RO_0002433  a           owl:ObjectProperty ;
        rdfs:label          "contributes to morphology of" ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:IAO_0000115     "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002348  a           owl:ObjectProperty ;
        rdfs:label          "results in commitment to"@en ;
        rdfs:range          obo:CL_0000000 ;
        rdfs:subPropertyOf  obo:RO_0002295 ;
        obo:IAO_0000112     "an annotation of gene X to cell commitment with results_in_commitment_to CL:0000540 (neuron) means that at the end of the process an unspecified cell has been specified and determined to develop into a neuron." ;
        obo:IAO_0000115     "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI .

obo:RO_0002222  a           owl:ObjectProperty ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." ;
        dc:source           "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1"^^xsd:anyURI ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002614  a           owl:ObjectProperty ;
        rdfs:comment        "In the Gene Ontology association model, this corresponds to the With/From field" ;
        rdfs:label          "is evidence with support from" ;
        rdfs:subPropertyOf  obo:RO_0002616 ;
        obo:IAO_0000112     "An instance of a sequence similarity evidence (ECO:0000044) that uses a homologous sequence UniProtKB:P12345 as support." ;
        obo:IAO_0000115     "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." .

obo:RO_0002403  a               owl:ObjectProperty ;
        rdfs:comment            "Likely to be obsoleted. See:\nhttps://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit" ;
        rdfs:label              "obsolete has indirect output" ;
        obo:IAO_0000114         obo:IAO_0000428 ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:deprecated          true ;
        owl:propertyChainAxiom  []  .

obo:BFO_0000051  a          owl:ObjectProperty ;
        rdfs:subPropertyOf  obo:RO_0002131 .

obo:RO_0002529  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "is downstream of sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002527 ;
        obo:IAO_0000115        "x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y." ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:inverseOf          obo:RO_0002529 .

obo:RO_0002011  a               owl:ObjectProperty ;
        rdfs:label              "regulates transport of" ;
        obo:IAO_0000115         "A relationship that holds between a  process that regulates a transport process and the entity transported by that process." ;
        obo:IAO_0000117         "David Osumi-Sutherland" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002590  a           owl:ObjectProperty ;
        rdfs:label          "results in disassembly of" ;
        rdfs:subPropertyOf  obo:RO_0002586 , obo:RO_0002592 .

obo:RO_0002107  a           owl:ObjectProperty ;
        rdfs:comment        "Expands to: has_part some ('type II terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ;
        rdfs:label          "synapsed_via_type_II_bouton_to"@en ;
        rdfs:subPropertyOf  obo:RO_0002120 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "A relation between a motor neuron and a muscle that it synapses to via a type II bouton." ;
        obo:IAO_0000117     "David Osumi-Sutherland" , "Marta Costa" ;
        obo:IAO_0000424     "BFO_0000051 some (GO_0061175 that BFO_0000051 some (that BFO_0000051 some (GO_0045202 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ;
        obo:RO_0001900      obo:RO_0001901 ;
        owl:inverseOf       obo:RO_0002108 .

obo:RO_0004029  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease has feature" ;
        rdfs:range               []  ;
        rdfs:subPropertyOf       obo:RO_0040035 ;
        obo:IAO_0000115          "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-12-26T19:50:53Z"^^xsd:dateTime .

obo:RO_0002560  a           owl:AnnotationProperty ;
        rdfs:label          "is asymmetric relational form of process class" ;
        rdfs:subPropertyOf  obo:RO_0002562 ;
        obo:IAO_0000115     "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x subject-partner-in p, y object-partner-in p" ;
        foaf:page           "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_0002083  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002475  a           owl:AnnotationProperty ;
        rdfs:label          "has no connections with" ;
        rdfs:subPropertyOf  obo:RO_0002420 ;
        obo:IAO_0000112     "'pectoral appendage skeleton' has no connections with 'pelvic appendage skeleton'" ;
        obo:IAO_0000115     "A is has_no_connections_with B if there are no parts of A or B that have a connection with the other." ;
        obo:IAO_0000118     "shares no connection with" ;
        obo:IAO_0000425     "Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: (BFO_0000050 some ?X) and (RO_0002170 some (BFO_0000050 some ?Y))" .

obo:RO_0002264  a                    owl:ObjectProperty ;
        rdfs:label                   "acts upstream of or within" ;
        rdfs:seeAlso                 <http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within> ;
        rdfs:subPropertyOf           obo:RO_0002500 ;
        obo:IAO_0000112              "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." ;
        obo:IAO_0000115              "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ;
        oboInOwl1:hasRelatedSynonym  "affects" ;
        owl:propertyChainAxiom       []  .

obo:RO_0002530  a              owl:ObjectProperty ;
        rdfs:label             "is immediately downstream of sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002529 , obo:RO_0002515 ;
        obo:IAO_0000112        "A 3'UTR is immediately downstream of the sequence of the CDS from the same monocistronic transcript" ;
        obo:IAO_0000115        "x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:RO_0002575         obo:RO_0002529 ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0002179  a           owl:ObjectProperty ;
        rdfs:label          "drains"@en ;
        rdfs:subPropertyOf  obo:RO_0002170 ;
        obo:IAO_0000115     "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." ;
        obo:IAO_0000116     "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20064205> .

obo:RO_0002445  a                  owl:ObjectProperty ;
        rdfs:label                 "parasitized by" ;
        rdfs:seeAlso               "http://eol.org/schema/terms/hasParasite" ;
        rdfs:subPropertyOf         obo:RO_0002453 , obo:RO_0002443 ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000118            "has parasite" , "parasitised by" ;
        oboInOwl1:hasExactSynonym  "directly parasitized by" ;
        oboInOwl1:inSubset         subsets:ro-eco .

obo:RO_0001022  a           owl:ObjectProperty ;
        rdfs:label          "has allergic trigger"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000112     "penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334)" ;
        obo:IAO_0000115     "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." .

obo:RO_0002234  a               owl:ObjectProperty ;
        rdfs:label              "has output"@en ;
        rdfs:subPropertyOf      obo:RO_0000057 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "produces" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:inverseOf           obo:RO_0002353 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002626  a           owl:ObjectProperty ;
        rdfs:label          "kills" ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        obo:IAO_0000119     "https://github.com/jhpoelen/eol-globi-data/issues/143" ;
        owl:inverseOf       obo:RO_0002627 .

obo:RO_0002500  a           owl:ObjectProperty ;
        rdfs:label          "causal agent in process" ;
        rdfs:subPropertyOf  obo:RO_0002595 ;
        obo:IAO_0000115     "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        owl:inverseOf       obo:RO_0002608 .

obo:RO_0004030  a                owl:ObjectProperty ;
        rdfs:label               "disease arises from structure" ;
        rdfs:range               obo:CARO_0000003 ;
        rdfs:subPropertyOf       obo:RO_0004019 ;
        obo:IAO_0000115          "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-12-26T19:58:44Z"^^xsd:dateTime .

obo:BFO_0000063  rdfs:subPropertyOf  obo:RO_0002222 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002023  a                owl:ObjectProperty ;
        rdfs:label               "directly negatively regulated by" ;
        rdfs:subPropertyOf       obo:RO_0002022 ;
        obo:IAO_0000115          "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-09-17T13:52:38Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0002630 .

obo:RO_0002204  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000004 ;
        rdfs:domain             []  ;
        rdfs:label              "gene product of"@en ;
        rdfs:range              obo:BFO_0000002 ;
        rdfs:range              []  ;
        rdfs:subPropertyOf      obo:RO_0002330 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" ;
        obo:IAO_0000116         "We would like to be able to express the rule: if t transcribed from g, and t is a noncoding RNA and has an evolved function, then t has gene product g." ;
        obo:IAO_0000117         "Chris Mungall"@en ;
        owl:inverseOf           obo:RO_0002205 ;
        owl:propertyChainAxiom  []  .

:z      a       swrl:Variable .

obo:RO_0002572  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000141 ;
        rdfs:label          "luminal space of" ;
        rdfs:subPropertyOf  obo:RO_0002571 ;
        obo:IAO_0000115     "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0004000  a                owl:ObjectProperty ;
        rdfs:domain              obo:BFO_0000017 ;
        rdfs:label               "condition has genetic basis in" ;
        rdfs:range               []  ;
        rdfs:subPropertyOf       obo:RO_0002410 ;
        obo:IAO_0000232          "Do not use this relation directly. It is intended as a grouping for a more specific relations" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:38:20Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004010 .

obo:RO_0002180  a           owl:ObjectProperty ;
        rdfs:label          "has component"@en ;
        rdfs:seeAlso        <http://ontologydesignpatterns.org/wiki/Submissions:Componency> ;
        rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
        obo:IAO_0000116     "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." ;
        obo:IAO_0000232     "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit."@en ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:GO_0085030  rdfs:subClassOf  []  .

obo:RO_0009005  a           owl:ObjectProperty , owl:IrreflexiveProperty ;
        rdfs:label          "has primary substance added"@en ;
        rdfs:subPropertyOf  obo:RO_0009001 ;
        obo:IAO_0000112     "bread 'has primary substance added' some 'flour'"@en ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "'has primary substance added' indicates that an entity has had the given substance added to it in a proportion greater than any other added substance."@en ;
        obo:IAO_0000117     "Damion Dooley" .

obo:RO_0002487  a        owl:ObjectProperty ;
        rdfs:domain      obo:BFO_0000002 ;
        rdfs:domain      []  ;
        rdfs:label       "relation between structure and stage" ;
        rdfs:range       obo:BFO_0000003 ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage." .

obo:BFO_0000003  rdfs:subClassOf  []  .

obo:RO_0002150  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000004 ;
        rdfs:label          "continuous with"@en ;
        rdfs:range          obo:BFO_0000004 ;
        rdfs:seeAlso        "FMA:85972" ;
        rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "X continuous_with Y if and only if X and Y share a fiat boundary." ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        obo:IAO_0000118     "connected to" ;
        obo:IAO_0000232     "The label for this relation was previously connected to. I relabeled this to \"continuous with\". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint)" ;
        obo:RO_0001900      obo:RO_0001901 .

obo:RO_0002542  a           owl:AnnotationProperty ;
        rdfs:label          "end, years post birth" ;
        rdfs:subPropertyOf  obo:RO_0002538 ;
        obo:IAO_0000115     "Count of number of years intervening between the end of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 1 for this property, and the period during which the child is one year old has the value 2" .

obo:RO_0002457  a           owl:ObjectProperty ;
        rdfs:label          "acquires nutrients from" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Intended to be used when the target of the relation is not itself consumed, and does not have integral parts consumed, but provided nutrients in some other fashion." ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002469 .

obo:RO_0002331  a               owl:ObjectProperty ;
        rdfs:label              "involved in"@en ;
        rdfs:seeAlso            <http://wiki.geneontology.org/index.php/Involved_in> ;
        rdfs:subPropertyOf      obo:RO_0002217 , obo:RO_0002431 ;
        obo:IAO_0000115         "c involved_in p if and only if c enables some process p', and p' is part of p" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "enables part of" , "actively involved in" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002246  a           owl:ObjectProperty ;
        rdfs:label          "under-expressed in" ;
        rdfs:subPropertyOf  obo:RO_0002206 ;
        obo:IAO_0000115     "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." .

obo:RO_0002638  a           owl:ObjectProperty ;
        rdfs:label          "intercellular endoparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002634 ;
        obo:IAO_0000115     "A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells." ;
        obo:IAO_0000119     <https://en.wikipedia.org/wiki/Parasitism#Types> ;
        owl:inverseOf       obo:RO_0002639 .

obo:RO_0002120  a              owl:ObjectProperty ;
        rdfs:comment           "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n   has_part some (\n      ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t   ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ;
        rdfs:domain            []  ;
        rdfs:label             "synapsed to"@en ;
        rdfs:subPropertyOf     obo:RO_0000302 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n        "@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en , "Chris Mungall"@en ;
        obo:IAO_0000424        "<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002512  a           owl:ObjectProperty ;
        rdfs:domain         []  ;
        rdfs:label          "ribosomal translation of" ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002330 ;
        obo:IAO_0000115     "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        owl:inverseOf       obo:RO_0002513 .

obo:RO_0002427  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "causally downstream of or within" ;
        rdfs:subPropertyOf  obo:RO_0002501 ;
        obo:IAO_0000115     "inverse of causally upstream of or within" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002301  a           owl:ObjectProperty ;
        rdfs:label          "results in developmental regression of"@en ;
        rdfs:subPropertyOf  obo:RO_0002552 ;
        obo:IAO_0000112     "every mullerian duct regression (GO:0001880) results in regression of some mullerian duct (UBERON:0003890)" ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "May be merged into parent relation" .

obo:RO_0003302  a           owl:ObjectProperty ;
        rdfs:comment        "Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to.\n\nEnvironmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions." ;
        rdfs:label          "causes or contributes to condition"@en ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000112     "The genetic variant 'NM_007294.3(BRCA1):c.110C>A (p.Thr37Lys)' casues or contributes to the disease  'familial breast-ovarian cancer'.\n\nAn environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease 'skin cancer'." ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ;
        obo:IAO_0000116     "Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! 'has phenotype' and RO:0002201 ! 'phenotype of'." .

foaf:image  a   owl:Class .

obo:RO_0002216  a               owl:ObjectProperty ;
        rdfs:label              "capable of part of"@en ;
        rdfs:seeAlso            <https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity> ;
        rdfs:subPropertyOf      obo:RO_0002500 , obo:RO_0002328 ;
        obo:IAO_0000115         "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "has function in" ;
        obo:IAO_0000424         "RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002608  a           owl:ObjectProperty ;
        rdfs:label          "process has causal agent" ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "Inverse of 'causal agent in process'" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> .

obo:RO_0002005  a              owl:ObjectProperty ;
        rdfs:domain            obo:CARO_0000003 ;
        rdfs:label             "innervated_by"@en ;
        rdfs:range             obo:CARO_0001001 ;
        obo:IAO_0000117        "David Osumi-Sutherland" ;
        cito:citesAsAuthority  "http://www.ncbi.nlm.nih.gov/pubmed/22402613"^^xsd:anyURI ;
        owl:inverseOf          obo:RO_0002134 .

obo:RO_0004012  a                owl:ObjectProperty ;
        rdfs:label               "is causal loss of function germline mutation of in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_410295> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:56:06Z"^^xsd:dateTime .

oboInOwl1:SubsetProperty
        a           owl:AnnotationProperty ;
        rdfs:label  "subset_property" .

obo:RO_0002584  a               owl:ObjectProperty ;
        rdfs:label              "has part structure that is capable of" ;
        rdfs:subPropertyOf      obo:RO_0002328 , obo:RO_0002595 ;
        obo:IAO_0000112         "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" ;
        obo:IAO_0000115         "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002373  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "has muscle insertion"@en ;
        rdfs:seeAlso        <http://dbpedia.org/property/insertion> ;
        rdfs:subPropertyOf  obo:RO_0002567 , obo:RO_0002371 ;
        obo:IAO_0000115     "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone."@en ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "Wikipedia:Insertion_(anatomy)"@en .

obo:BFO_0000015  rdfs:subClassOf  []  .

obo:RO_0002162  a               owl:ObjectProperty ;
        rdfs:comment            "Connects a biological entity to its taxon of origin." ;
        rdfs:label              "in taxon" ;
        rdfs:range              obo:CARO_0001010 ;
        rdfs:seeAlso            <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf      obo:RO_0002320 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." ;
        obo:IAO_0000117         "Jennifer Deegan" , "Chris Mungall"@en ;
        obo:IAO_0000119         <http://www.ncbi.nlm.nih.gov/pubmed/20973947> , <http://www.ncbi.nlm.nih.gov/pubmed/17921072> ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002554  a                    owl:ObjectProperty ;
        rdfs:label                   "hyperparasitized by" ;
        rdfs:subPropertyOf           obo:RO_0002453 ;
        obo:IAO_0000115              "inverse of hyperparasite of" ;
        obo:IAO_0000117              "Chris Mungall" ;
        oboInOwl1:hasRelatedSynonym  "has epiparasite" , "hyperparasitoidized by" , "has hyperparasite" ;
        oboInOwl1:inSubset           obo:RO_0002259 , subsets:ro-eco ;
        owl:propertyChainAxiom       []  .

obo:RO_0002469  a           owl:ObjectProperty ;
        rdfs:label          "provides nutrients for" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002343  a           owl:ObjectProperty ;
        rdfs:label          "results in growth of"@en ;
        rdfs:subPropertyOf  obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000112     "'pollen tube growth' results_in growth_of some 'pollen tube'" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002258  a           owl:ObjectProperty ;
        rdfs:comment        "This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from" ;
        rdfs:domain         obo:BFO_0000002 ;
        rdfs:label          "developmentally preceded by"@en ;
        rdfs:range          obo:BFO_0000002 ;
        rdfs:subPropertyOf  obo:RO_0002324 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" ;
        obo:IAO_0000116     false ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "In general you should not use this relation to make assertions - use one of the more specific relations below this one" ;
        owl:inverseOf       obo:RO_0002286 .

oboInOwl1:created_by  a  owl:AnnotationProperty .

obo:RO_0002132  a              owl:ObjectProperty ;
        rdfs:domain            obo:CARO_0001001 ;
        rdfs:label             "has fasciculating neuron projection"@en ;
        rdfs:range             []  ;
        rdfs:subPropertyOf     obo:RO_0002131 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it."@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en ;
        obo:IAO_0000118        "has fasciculating component"@en ;
        obo:IAO_0000426        "(forall (?x ?y) \n\t(iff \n\t\t(has_fasciculating_neuron_projection ?x ?y)\n\t\t(exists (?nps ?npbs)\t\t\n\t\t\t(and \n\t\t\t\t(\"neuron projection bundle ; CARO_0001001\" ?x)\n\t\t\t\t(\"neuron projection ; GO0043005\" ?y)\n\t\t\t\t(\"neuron projection segment ; CARO_0001502\" ?nps)\n\t\t\t\t(\"neuron projection bundle segment ; CARO_0001500\" ?npbs)\n\t\t\t\t(part_of ?nps ?y)\n\t\t\t\t(part_of ?npbs ?x)\n\t\t\t\t(part_of ?nps ?npbs)\n\t\t\t\t(forall (?npbss)\n\t\t\t\t\t(if\n\t\t\t\t\t\t(and \n\t\t\t\t\t\t\t(\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss)\n\t\t\t\t\t\t\t(part_of ?npbss ?npbs) \n\t\t\t\t\t\t)\n\t\t\t\t\t\t(overlaps ?nps ?npbss)\n\t\t\t\t\t))))))\n\n\n" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002524  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "has subsequence" ;
        rdfs:subPropertyOf     obo:BFO_0000051 , obo:RO_0002526 , obo:RO_0002522 ;
        obo:IAO_0000115        "x has subsequence y iff all of the sequence parts of x are sequence parts of y" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "contains" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:inverseOf          obo:RO_0002525 .

obo:RO_0002439  a           owl:ObjectProperty ;
        rdfs:label          "preys on" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/preysUpon" , "http://www.inaturalist.org/observations/2942824" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000112     "Baleen whale preys on krill" , "A wasp killing a Monarch larva in order to feed to offspring [http://www.inaturalist.org/observations/2942824]" ;
        obo:IAO_0000115     "An interaction relationship involving a predation process, where the subject kills the target in order to eat it or to feed to siblings, offspring or group members" ;
        obo:IAO_0000117     "Katja Shulz" , "Jorrit Poelen" , "Chris Mungall" ;
        obo:IAO_0000118     "is subject of predation interaction with" , "preys upon" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002458 .

obo:RO_0002313  a               owl:ObjectProperty ;
        rdfs:label              "transports or maintains localization of"@en ;
        rdfs:subPropertyOf      obo:RO_0002337 , obo:RO_0040036 ;
        obo:IAO_0000115         "Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment)  and the outcome of this process is to regulate the localization of c." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "regulates localization of" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002228  a           owl:ObjectProperty ;
        rdfs:label          "facultative parasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relations of parasite-of in which the parasite that can complete its life cycle independent of a host." .

obo:RO_0002409  a               owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label              "indirectly inhibits"@en ;
        rdfs:subPropertyOf      obo:RO_0002212 ;
        obo:IAO_0000114         obo:IAO_0000428 ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "indirectly negatively regulates" ;
        obo:RO_0002579          obo:RO_0002212 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002102  a               owl:ObjectProperty ;
        rdfs:domain             obo:CL_0000540 ;
        rdfs:label              "axon synapses in"@en ;
        rdfs:subPropertyOf      obo:RO_0002113 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a neuron and some structure its axon forms (chemical) synapses in."@en ;
        obo:IAO_0000117         "David Osumi-Sutherland"@en , "David Osumi-Sutherland" , "Chris Mungall"@en ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/BFO_0000051> some (\n   <http://purl.obolibrary.org/obo/GO_0030424> and <http://purl.obolibrary.org/obo/BFO_0000051> some (\n      <http://purl.obolibrary.org/obo/GO_0042734> and <http://purl.obolibrary.org/obo/BFO_0000050> some (\n         <http://purl.obolibrary.org/obo/GO_0045202> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)))" ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf           obo:RO_0002110 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002596  a               owl:ObjectProperty ;
        rdfs:label              "capable of regulating" ;
        rdfs:subPropertyOf      obo:RO_0002500 ;
        obo:IAO_0000112         "pyrethroid -> growth" ;
        obo:IAO_0000115         "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        owl:propertyChainAxiom  []  .

obo:RO_0004024  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease causes disruption of" ;
        rdfs:range               obo:BFO_0000015 ;
        rdfs:subPropertyOf       obo:RO_0004023 ;
        obo:IAO_0000115          "A relationship between a disease and a process where the disease process disrupts the execution of the process." ;
        obo:IAO_0000589          "disease causes disruption of (disease to process)" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:51:09Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  ;
        owl:propertyChainAxiom   []  .

obo:RO_0002017  a                owl:ObjectProperty ;
        rdfs:comment             "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ;
        rdfs:label               "has component activity" ;
        rdfs:subPropertyOf       obo:RO_0002018 ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:44:33Z"^^xsd:dateTime .

obo:RO_0008505  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0001010 ;
        rdfs:label          "creates habitat for" ;
        rdfs:range          obo:CARO_0001010 ;
        rdfs:subPropertyOf  obo:RO_0002321 ;
        obo:IAO_0000115     "An interaction relationship wherein one organism creates a structure or environment that is lived in by another organism." .

obo:RO_0002470  a           owl:ObjectProperty ;
        rdfs:label          "eats" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "is subject of eating interaction with" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002385  a           owl:ObjectProperty ;
        rdfs:label          "has potential to developmentally contribute to"@en ;
        rdfs:subPropertyOf  obo:RO_0002384 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y"@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002440  a               owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label              "symbiotically interacts with" ;
        rdfs:subPropertyOf      obo:RO_0002574 ;
        obo:IAO_0000115         "A biotic interaction in which the two organisms live together in more or less intimate association." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ;
        obo:IAO_0000232         "We follow GO and PAMGO in using 'symbiosis' as the broad term encompassing mutualism through parasitism" ;
        obo:RO_0002561          obo:GO_0044403 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002174  a           owl:AnnotationProperty ;
        rdfs:comment        "This relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take ongoing coordinated effort to resolve. Example: metencephalon in teleost" ;
        rdfs:label          "dubious for taxon"@en ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002172 ;
        obo:IAO_0000115     "S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T." ;
        obo:IAO_0000117     "https://orcid.org/0000-0002-6601-2165" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> .

obo:RO_0002566  a               owl:ObjectProperty ;
        rdfs:label              "causally influences" ;
        rdfs:subPropertyOf      obo:RO_0002506 ;
        obo:IAO_0000115         "Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589         "causally influences (material entity to material entity)" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_HOM0000003  rdfs:subPropertyOf  obo:RO_0002320 .

obo:RO_0002089  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002355  a           owl:ObjectProperty ;
        rdfs:label          "results in structural organization of"@en ;
        rdfs:subPropertyOf  obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000115     "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." ;
        obo:IAO_0000117     "Chris Mungall" .

cito:citesAsAuthority
        a       owl:AnnotationProperty .

obo:RO_0000057  owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002536  a           owl:AnnotationProperty ;
        rdfs:label          "measurement property has unit" ;
        rdfs:subPropertyOf  obo:RO_0002423 .

obo:RO_0002410  a        owl:ObjectProperty ;
        rdfs:label       "causally related to"@en ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "This relation groups causal relations between material entities and causal relations between processes" ;
        obo:IAO_0000116  "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." .

obo:RO_0002325  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "colocalizes with"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000112     "Clp1p relocalizes from the nucleolus to the spindle and site of cell division; i.e. it is associated transiently with the spindle pole body and the contractile ring (evidence from GFP fusion). Clp1p colocalizes_with spindle pole body (GO:0005816) and contractile ring (GO:0005826)" ;
        obo:IAO_0000115     "a colocalizes_with b if and only if  a is transiently or peripherally associated with b[GO]." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.geneontology.org/GO.annotation.conventions.shtml#colocalizes_with" ;
        obo:IAO_0000232     "In the context of the Gene Ontology, colocalizes_with may be used for annotating to cellular component terms[GO]" ;
        dc:creator          "Gene Ontology Consortium" .

obo:RO_0002114  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('type III terminal button' that has_part some ('pre-synaptic membrane' that part_of some ('synapse' that has_part some ('post-synaptic membrane' that part_of some ?Y))))" ;
        rdfs:label             "synapsed_via_type_III_bouton_to"@en ;
        rdfs:subPropertyOf     obo:RO_0002120 ;
        obo:IAO_0000115        "A relation between a motor neuron and a muscle that it synapses to via a type III bouton." ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0061177 that BFO_0000051 some (that BFO_0000051 some (GO_0097467 that BFO_0000051 some ( that BFO_0000050 some ?Y))))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf          obo:RO_0002115 .

obo:RO_0002506  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "causal relation between material entities" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000116     "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000232     "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." .

obo:RO_0002029  a                owl:DatatypeProperty ;
        rdfs:comment             "This could be used to record the increased infant morality rate in some population compared to wild-type.  For examples of usage see http://purl.obolibrary.org/obo/FBcv_0000351 and subclasses." ;
        rdfs:label               "has increased age-specific mortality rate"@en ;
        rdfs:range               []  ;
        obo:IAO_0000115          "Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2018-05-22T16:43:28Z"^^xsd:dateTime .

obo:RO_0002090  obo:IAO_0000117  "David Osumi-Sutherland" ;
        obo:RO_0002575          obo:BFO_0000063 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002482  a           owl:ObjectProperty ;
        rdfs:label          "is ubiquitination" ;
        rdfs:subPropertyOf  obo:RO_0002564 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0004006  a                owl:ObjectProperty ;
        rdfs:label               "has partial material basis in germline mutation in" ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:46:57Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004016 .

obo:RO_0002578  a           owl:ObjectProperty ;
        rdfs:label          "directly regulates" ;
        rdfs:subPropertyOf  obo:RO_0002412 , obo:RO_0002211 ;
        obo:IAO_0000115     "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "directly regulates (processual)" ;
        obo:RO_0002575      obo:RO_0002211 .

obo:RO_0002452  a           owl:ObjectProperty ;
        rdfs:domain         obo:OGMS_0000031 ;
        rdfs:label          "has symptom" ;
        rdfs:subPropertyOf  obo:RO_0002200 ;
        obo:IAO_0000115     "A relation that holds between a disease or an organism and a phenotype" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002241  a           owl:ObjectProperty ;
        rdfs:label          "has exposure stressor" ;
        rdfs:subPropertyOf  obo:RO_0002309 ;
        obo:IAO_0000115     "A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event." ;
        obo:IAO_0000119     "ExO:0000000" .

obo:RO_0002633  a           owl:ObjectProperty ;
        rdfs:label          "has ectoparasite" ;
        rdfs:subPropertyOf  obo:RO_0002445 ;
        obo:IAO_0000115     "inverse of ectoparasite of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002156  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "derived by descent from" ;
        rdfs:subPropertyOf  obo:RO_0002320 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." ;
        obo:IAO_0000118     "evolutionarily_descended_from" , "ancestral_stucture_of" ;
        owl:inverseOf       obo:RO_0002157 .

obo:RO_0002548  a           owl:AnnotationProperty ;
        rdfs:label          "end, days post coitum" ;
        rdfs:subPropertyOf  obo:RO_0002538 ;
        obo:IAO_0000115     "Count of number of days intervening between the end of the stage and the time of coitum." .

obo:RO_0002422  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion on an object property"@en ;
        rdfs:subPropertyOf  obo:RO_0002421 ;
        obo:IAO_0000115     "Used to annotate object properties to describe a logical meta-property or characteristic of the object property." .

<urn:swrl#g2>  a  swrl:Variable .

obo:RO_0002337  a        owl:ObjectProperty ;
        rdfs:domain      obo:BFO_0000015 ;
        rdfs:label       "related via localization to"@en ;
        rdfs:range       obo:BFO_0000002 ;
        obo:IAO_0000115  "A relationship that holds via some process of localization" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is a grouping relation." .

obo:RO_0002211  a               owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000015 ;
        rdfs:label              "regulates"@en ;
        rdfs:range              obo:BFO_0000015 ;
        rdfs:subPropertyOf      obo:RO_0002411 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." ;
        obo:IAO_0000116         "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit" ;
        obo:IAO_0000117         "David Hill" , "Chris Mungall" , "Tanya Berardini" ;
        obo:IAO_0000119         "GO" ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000232         "Regulation precludes parthood; the regulatory process may not be within the regulated process." ;
        obo:IAO_0000589         "regulates (processual)" ;
        obo:IAO_0000600         false ;
        owl:inverseOf           obo:RO_0002334 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002603  a           owl:AnnotationProperty ;
        rdfs:label          "is approximately equivalent to" ;
        rdfs:subPropertyOf  obo:RO_0002602 ;
        obo:IAO_0000115     "x is approximately equivalent to y if it is the case that x is equivalent, identical or near-equivalent to y" ;
        obo:IAO_0000232     "The precise meaning of this property is dependent upon some contexts. It is intended to group multiple possible formalisms. Possibilities include a probabilistic interpretation, for example, Pr(x=y) > 0.95. Other possibilities include reified statements of belief, for example, \"Database D states that x=y\"" .

oboInOwl1:inSubset  a  owl:AnnotationProperty ;
        rdfs:label  "in_subset" .

obo:RO_0002518  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "has end sequence" ;
        rdfs:subPropertyOf     obo:RO_0002524 ;
        obo:IAO_0000112        "Every CDS has as an end sequence the stop codon for that transcript (note this follows from the SO definition of CDS, in which stop codons are included)" ;
        obo:IAO_0000115        "x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "ended by" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:inverseOf          obo:RO_0002519 .

obo:RO_0004048  a                owl:AnnotationProperty ;
        rdfs:label               "is directional form of" ;
        rdfs:subPropertyOf       obo:RO_0002422 ;
        obo:IAO_0000115          "Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be \"+\", \"-\" or \"0\"" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-03-13T23:59:29Z"^^xsd:dateTime .

obo:RO_0002000  rdfs:subPropertyOf  obo:RO_0002323 .

obo:RO_0003001  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "produced by"@en ;
        rdfs:range          obo:BFO_0000040 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "a produced_by b iff some process that occurs_in b has_output a." ;
        obo:IAO_0000117     "Melissa Haendel" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002494  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "transformation of" ;
        rdfs:subPropertyOf  obo:RO_0002202 ;
        obo:IAO_0000115     "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0003308  a           owl:ObjectProperty ;
        rdfs:label          "correlated with condition"@en ;
        rdfs:subPropertyOf  obo:RO_0002610 ;
        obo:IAO_0000115     "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." .

obo:RO_0004018  a                owl:ObjectProperty ;
        rdfs:label               "is basis for realizable" ;
        rdfs:subPropertyOf       obo:RO_0002410 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:20:29Z"^^xsd:dateTime .

obo:R0_0009004  a        owl:ObjectProperty ;
        rdfs:domain      obo:BFO_0000040 ;
        rdfs:label       "has consumer"@en ;
        rdfs:range       obo:CARO_0001010 ;
        obo:IAO_0000112  "sardine has consumer some homo sapiens"@en ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "'has consumer' is a relation between a material entity and an organism in which the former can normally be digested or otherwise absorbed by the latter without immediate or persistent ill effect."@en ;
        obo:IAO_0000117  "Damion Dooley" .

<urn:swrl#a2>  a  swrl:Variable .

obo:RO_0002464  a        owl:ObjectProperty ;
        rdfs:label       "helper property (not for use in curation)" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." .

obo:RO_0002379  a               owl:ObjectProperty ;
        rdfs:label              "spatially coextensive with"@en ;
        rdfs:subPropertyOf      obo:RO_0002131 ;
        obo:IAO_0000112         "A lump of clay and a statue" ;
        obo:IAO_0000115         "x spatially_coextensive_with y if and inly if x and y have the same location" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000232         "This relation is added for formal completeness. It is unlikely to be used in many practical scenarios" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002253  a           owl:ObjectProperty ;
        rdfs:label          "has connecting branch" ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000115     "inverse of connecting branch of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002434  a                  owl:SymmetricProperty , owl:ObjectProperty ;
        rdfs:domain                obo:BFO_0000040 ;
        rdfs:label                 "interacts with" ;
        rdfs:range                 obo:BFO_0000040 ;
        rdfs:seeAlso               "http://purl.obolibrary.org/obo/MI_0914"^^xsd:anyURI ;
        obo:IAO_0000115            "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ;
        obo:IAO_0000116            "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." , "Considering relabeling as 'pairwise interacts with'"^^xsd:anyURI ;
        obo:IAO_0000117            "Chris Mungall" ;
        obo:IAO_0000232            "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." ;
        oboInOwl1:hasExactSynonym  "in pairwise interaction with" ;
        oboInOwl1:inSubset         subsets:ro-eco ;
        foaf:page                  "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_0002349  a           owl:ObjectProperty ;
        rdfs:label          "results in determination of"@en ;
        rdfs:range          obo:CL_0000000 ;
        rdfs:subPropertyOf  obo:RO_0002295 ;
        obo:IAO_0000115     "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI .

obo:RO_0002223  rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002615  a        owl:ObjectProperty ;
        rdfs:label       "has model" ;
        obo:IAO_0000115  "Inverse of is-model-of" ;
        owl:inverseOf    obo:RO_0003301 .

obo:RO_0002591  a           owl:ObjectProperty ;
        rdfs:label          "results in remodeling of" ;
        rdfs:subPropertyOf  obo:RO_0002592 , obo:RO_0002233 .

obo:RO_0002012  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000003 ;
        rdfs:label          "occurent part of" ;
        rdfs:range          obo:BFO_0000003 ;
        rdfs:subPropertyOf  obo:RO_0002418 , obo:BFO_0000050 ;
        obo:IAO_0000115     "A part of relation that applies only between occurents." .

obo:RO_0002404  a           owl:ObjectProperty ;
        rdfs:label          "causally downstream of"@en ;
        rdfs:subPropertyOf  obo:RO_0002427 , obo:BFO_0000062 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "inverse of upstream of" ;
        obo:IAO_0000117     "Chris Mungall" ;
        owl:inverseOf       obo:RO_0002411 .

obo:RO_0009501  a                  owl:ObjectProperty ;
        rdfs:domain                obo:BFO_0000017 ;
        rdfs:label                 "realized in response to"@en ;
        rdfs:range                 obo:BFO_0000015 ;
        rdfs:seeAlso               "https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit"^^xsd:anyURI ;
        rdfs:subPropertyOf         obo:RO_0002410 ;
        obo:IAO_0000112            "An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut)" , "A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions." , "Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph." ;
        obo:IAO_0000115            "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ;
        dc:contributor             "Chris Mungall" , "Austin Meier" , "Marie Angelique Laporte" , "David Osumi-Sutherland" ;
        oboInOwl1:hasExactSynonym  "triggered by process" ;
        owl:propertyChainAxiom     []  .

obo:RO_0002380  a               owl:ObjectProperty ;
        rdfs:label              "branching part of"@en ;
        rdfs:range              []  ;
        rdfs:seeAlso            "FMA:85994" ;
        rdfs:subPropertyOf      obo:BFO_0000050 , obo:RO_0002375 ;
        obo:IAO_0000114         obo:IAO_0000428 ;
        obo:IAO_0000115         "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" ;
        obo:IAO_0000117         "Chris Mungall" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:inverseOf           obo:RO_0002569 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002295  a            owl:ObjectProperty ;
        rdfs:domain          obo:GO_0008150 ;
        rdfs:label           "results in developmental progression of"@en ;
        rdfs:range           obo:CARO_0000003 ;
        rdfs:seeAlso         <http://wiki.geneontology.org/index.php/Ontology_extensions> ;
        rdfs:subPropertyOf   obo:RO_0002324 ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000115      "p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." ;
        obo:IAO_0000116      "This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint." ;
        obo:IAO_0000117      "Chris Mungall" ;
        oboInOwl1:shorthand  "results_in_developmental_progression_of" .

obo:RO_0002108  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type II terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ;
        rdfs:label             "synapsed_by_via_type_II_bouton"@en ;
        rdfs:subPropertyOf     obo:RO_0002103 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "Relation between a muscle and a motor neuron that synapses to it via a type II bouton." ;
        obo:IAO_0000117        "Marta Costa" , "David Osumi-Sutherland" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061174 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))\n" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002561  a           owl:AnnotationProperty ;
        rdfs:label          "is symmetric relational form of process class" ;
        rdfs:subPropertyOf  obo:RO_0002562 ;
        obo:IAO_0000115     "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x partner-in p, y partner-in p" ;
        foaf:page           "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_0002084  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002476  a           owl:ObjectProperty ;
        rdfs:domain         obo:GO_0005634 ;
        rdfs:label          "child nucleus of" ;
        rdfs:range          obo:GO_0005634 ;
        rdfs:subPropertyOf  obo:RO_0002258 ;
        obo:IAO_0000112     "ABal nucleus child nucleus of ABa nucleus (in C elegans)" ;
        obo:IAO_0000115     "c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "This relation is primarily used in the worm anatomy ontology for representing lineage at the level of nuclei. However, it is applicable to any organismal cell lineage." .

obo:RO_0000052  rdfs:subPropertyOf  obo:RO_0002314 .

obo:RO_0002531  a              owl:ObjectProperty ;
        rdfs:label             "is immediately upstream of sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002515 , obo:RO_0002528 ;
        obo:IAO_0000112        "A 5'UTR is immediately upstream of the sequence of the CDS from the same monocistronic transcript" ;
        obo:IAO_0000115        "inverse of immediately downstream of" ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0002446  a                    owl:ObjectProperty ;
        rdfs:label                   "participates in a abiotic-biotic interaction with" ;
        rdfs:seeAlso                 <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
        rdfs:subPropertyOf           obo:RO_0002437 ;
        obo:IAO_0000112              "Porifiera attaches to substrate" ;
        obo:IAO_0000115              "A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored." ;
        obo:IAO_0000117              "Chris Mungall" ;
        oboInOwl1:hasRelatedSynonym  "semibiotically interacts with" ;
        oboInOwl1:inSubset           subsets:ro-eco .

obo:RO_0002320  a        owl:ObjectProperty ;
        rdfs:label       "evolutionarily related to"@en ;
        obo:IAO_0000115  "A relationship that holds via some environmental process" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." .

obo:RO_0002235  a           owl:ObjectProperty ;
        rdfs:label          "stem parasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host stem (PO:0009047)" .

obo:RO_0002627  a           owl:ObjectProperty ;
        rdfs:label          "is killed by" ;
        rdfs:subPropertyOf  obo:RO_0002574 .

obo:RO_0001023  a           owl:ObjectProperty ;
        rdfs:label          "has autoimmune trigger"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000115     "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." .

obo:RO_0002501  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000003 ;
        rdfs:label          "causal relation between processes" ;
        rdfs:range          obo:BFO_0000003 ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000232     "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." .

obo:RO_0004031  a                owl:ObjectProperty ;
        rdfs:label               "enables subfunction" ;
        rdfs:subPropertyOf       obo:RO_0002328 ;
        obo:IAO_0000115          "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-01-25T23:20:13Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002024  a                owl:ObjectProperty ;
        rdfs:label               "directly positively regulated by" ;
        rdfs:subPropertyOf       obo:RO_0002022 ;
        obo:IAO_0000115          "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-09-17T13:52:47Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0002629 .

obo:RO_0002416  a        owl:AnnotationProperty ;
        rdfs:label       "logical macro assertion"@en ;
        obo:IAO_0000115  "An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL." ;
        foaf:page        "https://github.com/oborel/obo-relations/wiki/ShortcutRelations"^^xsd:anyURI .

obo:RO_0002205  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000002 ;
        rdfs:label              "has gene product"@en ;
        rdfs:range              obo:BFO_0000004 ;
        rdfs:subPropertyOf      obo:RO_0002330 ;
        obo:IAO_0000112         "every HOTAIR lncRNA is the gene product of some HOXC gene" , "every sonic hedgehog protein (PR:000014841) is the gene product of some sonic hedgehog gene" ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" ;
        obo:IAO_0000117         "Chris Mungall"@en ;
        owl:propertyChainAxiom  []  .

obo:RO_0004001  a                owl:ObjectProperty ;
        rdfs:label               "has material basis in gain of function germline mutation in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_410295> , <http://www.orpha.net/ORDO/Orphanet_410296> ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:45:20Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004011 .

obo:GO_0085031  rdfs:subClassOf  []  .

obo:RO_0002573  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000020 ;
        rdfs:label          "has modifier" ;
        rdfs:range          obo:BFO_0000020 ;
        obo:IAO_0000115     "A relation that holds between an attribute or a qualifier and another attribute." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20064205> ;
        obo:IAO_0000232     "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002488  a               owl:ObjectProperty ;
        rdfs:label              "existence starts during" ;
        rdfs:subPropertyOf      obo:RO_0002496 , obo:RO_0002490 ;
        obo:IAO_0000115         "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002151  a           owl:ObjectProperty ;
        rdfs:label          "partially overlaps"@en ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x" ;
        obo:IAO_0000116     "We would like to include disjointness axioms with part_of and has_part, however this is not possible in OWL2 as these are non-simple properties and hence cannot appear in a disjointness axiom" ;
        obo:IAO_0000118     "proper overlaps" ;
        obo:IAO_0000426     "(forall (?x ?y) \n\t(iff \n\t\t(proper_overlaps ?x ?y)\n\t\t(and \n\t\t\t(overlaps ?x ?y)\n\t\t\t(not (part_of ?x ?y)) \n\t\t\t(not (part_of ?y ?x)))))" ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002543  a           owl:AnnotationProperty ;
        rdfs:label          "start, months post birth" ;
        rdfs:subPropertyOf  obo:RO_0002537 ;
        obo:IAO_0000115     "Count of number of months intervening between the start of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 0 for this property, and the period during which the child is one month old has the value 1." .

obo:RO_0002458  a           owl:ObjectProperty ;
        rdfs:label          "preyed upon by" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/HasPredator" , "http://polytraits.lifewatchgreece.eu/terms/PRED" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000115     "inverse of preys on" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "is target of predation interaction with" , "has predator" ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002332  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000015 ;
        rdfs:label          "regulates levels of"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0002328 ;
        obo:IAO_0000112     "every cellular sphingolipid homeostasis process regulates_level_of some sphingolipid" ;
        obo:IAO_0000115     "p regulates levels of c if p regulates some amount (PATO:0000070) of c" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "regulates levels of (process to entity)" .

obo:RO_0002639  a           owl:ObjectProperty ;
        rdfs:label          "has intercellular endoparasite" ;
        rdfs:subPropertyOf  obo:RO_0002635 ;
        obo:IAO_0000115     "inverse of intercellular endoparasite of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002121  a               owl:ObjectProperty ;
        rdfs:domain             obo:CL_0000540 ;
        rdfs:label              "dendrite synapsed in"@en ;
        rdfs:subPropertyOf      obo:RO_0002110 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a neuron and some structure  (e.g.- a brain region) in which its dendrite receives synaptic input.\n\n\t"@en ;
        obo:IAO_0000117         "David Osumi-Sutherland"@en , "Chris Mungall"@en ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/BFO_0000051> some (\n\t<http://purl.obolibrary.org/obo/GO_0030425> and <http://purl.obolibrary.org/obo/BFO_0000051> some (\n\t   http://purl.obolibrary.org/obo/GO_0042734 and <http://purl.obolibrary.org/obo/BFO_0000050> some (\n\t      <http://purl.obolibrary.org/obo/GO_0045202> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)))" ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002513  a           owl:ObjectProperty ;
        rdfs:domain         []  ;
        rdfs:label          "ribosomally translates to" ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002330 ;
        obo:IAO_0000115     "inverse of ribosomal translation of" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI .

obo:RO_0002428  a               owl:ObjectProperty ;
        rdfs:label              "involved in regulation of" ;
        rdfs:subPropertyOf      obo:RO_0002263 , obo:RO_0002431 ;
        obo:IAO_0000115         "c involved in regulation of p if c is involved in some p' and p' regulates some p" ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0000300  a              owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:domain            obo:CL_0000540 ;
        rdfs:label             "in neural circuit with"@en ;
        rdfs:range             obo:CL_0000540 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons."@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en ;
        obo:IAO_0000426        "(forall (?x ?y) \n\t(iff \n\t\t(neural_circuit_path  ?x ?y)\n\t\t(and\n\t\t\t(\"neuron ; CL_0000540\" ?x)\n\t\t\t(\"neuron ; CL_0000540\" ?y)\n\t\t\t(or \n\t\t\t\t(synapsed_by ?x ?y) \n\t\t\t\t(synapsed_to ?x ?y))))) \n\n(forall (...s ?x ?y ?z) \n\t(iff \n\t\t(neural_circuit_path  ...s ?x ?y ?z)\n\t\t(and\n\t\t\t(neural_circuit_path  ...s ?x ?y)\n\t\t\t(\"neuron ; CL_0000540\" ?z)\n\t\t\t(or \n\t\t\t\t(synapsed_by ?y ?z) \n\t\t\t\t(synapsed_to ?y ?z))))) \n\n(forall (?x ?y) \n\t(iff \n\t\t(in_neural_circuit_with ?x ?y)\n\t\t(exists (...s)\n\t\t\t(neural_circuit_path  ?x ...s ?y)))) " ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002302  a           owl:ObjectProperty ;
        rdfs:label          "is treated by substance" ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "Inverse of 'is substance that treats'" ;
        dc:creator          "cjm" ;
        oboInOwl1:inSubset  obo:RO_0002259 ;
        owl:inverseOf       obo:RO_0002606 .

obo:RO_0003303  a           owl:ObjectProperty ;
        rdfs:label          "causes condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." .

obo:RO_0002217  a           owl:ObjectProperty ;
        rdfs:label          "actively participates in"@en ;
        rdfs:subPropertyOf  obo:RO_0000056 ;
        obo:IAO_0000115     "x actively participates in y if and only if x participates in y and x realizes some active role" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "agent in" ;
        owl:inverseOf       obo:RO_0002218 .

obo:RO_0002609  a        owl:ObjectProperty ;
        rdfs:label       "obsolete related via dependence to" ;
        obo:IAO_0000115  "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
        obo:IAO_0000232  "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
        owl:deprecated   true .

obo:RO_0002006  a           owl:ObjectProperty ;
        rdfs:label          "has synaptic terminal of"@en ;
        rdfs:subPropertyOf  obo:RO_0002131 ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        owl:inverseOf       obo:RO_0002130 .

obo:RO_0004013  a                owl:ObjectProperty ;
        rdfs:label               "is causal germline mutation in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317343> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:56:40Z"^^xsd:dateTime .

<urn:swrl#w>  a  swrl:Variable .

obo:RO_0002585  a           owl:ObjectProperty ;
        rdfs:label          "results in closure of" ;
        rdfs:subPropertyOf  obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000116     "p 'results in closure of' c if and only if p is a developmental process and p results in a state of c changing from open to closed." .

obo:CARO_0000006  rdfs:subClassOf  []  .

obo:RO_0002374  a                  owl:ObjectProperty ;
        rdfs:comment               "A has_fused_element B does not imply that A has_part some B: rather than A has_part some B', where B' that has some evolutionary relationship to B."@en ;
        rdfs:label                 "derived from ancestral fusion of"@en ;
        rdfs:subPropertyOf         obo:RO_0002156 ;
        obo:IAO_0000112            false ;
        obo:IAO_0000114            obo:IAO_0000428 ;
        obo:IAO_0000115            "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat"@en ;
        obo:IAO_0000117            "Chris Mungall" , "Chris Mungall"@en ;
        obo:IAO_0000119            <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        oboInOwl1:hasBroadSynonym  "has fused element" .

obo:RO_0002640  a           owl:ObjectProperty ;
        rdfs:label          "intracellular endoparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002634 ;
        obo:IAO_0000115     "A sub-relation of endoparasite-of in which the parasite inhabits host cells." ;
        obo:IAO_0000119     <https://en.wikipedia.org/wiki/Parasitism#Types> ;
        owl:inverseOf       obo:RO_0002641 .

obo:RO_0002163  a           owl:ObjectProperty ;
        rdfs:label          "spatially disjoint from" ;
        rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "A is spatially_disjoint_from B if and only if they have no parts in common" ;
        obo:IAO_0000116     "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. "@en ;
        obo:IAO_0000117     "Chris Mungall"@en ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        obo:IAO_0000232     "Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy" ;
        obo:IAO_0000424     "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" ;
        obo:RO_0001900      obo:RO_0001901 ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        foaf:page           "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern"^^xsd:anyURI .

obo:RO_0002555  a           owl:ObjectProperty ;
        rdfs:label          "allelopath of" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/allelopathyYes" , "x is an allelopath of y iff  xis an organism produces one or more biochemicals that influence the growth, survival, and reproduction of y" ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://en.wikipedia.org/wiki/Allelopathy" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002344  a           owl:ObjectProperty ;
        rdfs:label          "results in transport to from or in"@en ;
        rdfs:subPropertyOf  obo:RO_0002337 ;
        obo:IAO_0000112     "'mitochondrial transport' results_in_transport_to_from_or_in some  mitochondrion (GO:0005739)" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002259  a           owl:AnnotationProperty ;
        rdfs:label          "defined by inverse" ;
        rdfs:subPropertyOf  oboInOwl1:SubsetProperty .

obo:RO_0002610  a        owl:ObjectProperty ;
        rdfs:label       "correlated with" ;
        obo:IAO_0000115  "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
        obo:IAO_0000232  "Groups both positive and negative correlation" .

obo:RO_0002525  a              owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:label             "is subsequence of" ;
        rdfs:subPropertyOf     obo:RO_0002526 , obo:RO_0002523 , obo:BFO_0000050 ;
        obo:IAO_0000115        "inverse of has subsequence" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "contained by" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        oboInOwl1:inSubset     obo:RO_0002259 .

obo:RO_0002314  a               owl:ObjectProperty ;
        rdfs:label              "inheres in part of"@en ;
        rdfs:seeAlso            <https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity> ;
        rdfs:subPropertyOf      obo:RO_0002502 ;
        obo:IAO_0000115         "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." ;
        obo:IAO_0000116         "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         <http://www.ncbi.nlm.nih.gov/pubmed/20064205> ;
        obo:RO_0001900          obo:RO_0001901 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002229  rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:GO_0016301  rdfs:subClassOf  []  .

obo:RO_0002103  a              owl:ObjectProperty ;
        rdfs:label             "synapsed by"@en ;
        rdfs:range             []  ;
        rdfs:subPropertyOf     obo:RO_0000301 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en , "Chris Mungall"@en ;
        obo:IAO_0000424        "<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:inverseOf          obo:RO_0002120 .

obo:RO_0002597  a               owl:ObjectProperty ;
        rdfs:label              "capable of negatively regulating" ;
        rdfs:subPropertyOf      obo:RO_0002596 ;
        obo:IAO_0000115         "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        owl:propertyChainAxiom  []  .

obo:RO_0004025  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease causes dysfunction of" ;
        rdfs:range               obo:CARO_0000006 ;
        rdfs:subPropertyOf       obo:RO_0004023 ;
        obo:IAO_0000589          "disease causes dysfunction of (disease to anatomical entity)" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:58:20Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002018  a                owl:ObjectProperty ;
        rdfs:domain              obo:BFO_0000015 ;
        rdfs:label               "has component process" ;
        rdfs:range               obo:BFO_0000015 ;
        rdfs:subPropertyOf       obo:RO_0002180 ;
        obo:IAO_0000115          "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:49:21Z"^^xsd:dateTime .

obo:RO_0008506  a           owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:domain         obo:CARO_0001010 ;
        rdfs:label          "ecologically co-occurs with" ;
        rdfs:range          obo:CARO_0001010 ;
        rdfs:subPropertyOf  obo:RO_0002321 ;
        obo:IAO_0000115     "An interaction relationship describing organisms that often occur together at the same time and space or in the same environment." .

obo:RO_0002471  a           owl:ObjectProperty ;
        rdfs:label          "is eaten by" ;
        rdfs:subPropertyOf  obo:RO_0002438 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "is target of eating interaction with" , "eaten by" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002386  a           owl:ObjectProperty ;
        rdfs:label          "has potential to developmentally induce"@en ;
        rdfs:subPropertyOf  obo:RO_0002384 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y"@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002260  a  owl:ObjectProperty .

obo:RO_0002175  a           owl:AnnotationProperty ;
        rdfs:label          "present in taxon"@en ;
        rdfs:seeAlso        <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
        rdfs:subPropertyOf  obo:RO_0002172 ;
        obo:IAO_0000115     "S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S" ;
        obo:IAO_0000117     "https://orcid.org/0000-0002-6601-2165" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> .

obo:RO_0002567  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "biomechanically related to" ;
        rdfs:range          obo:CARO_0000003 ;
        rdfs:subPropertyOf  obo:RO_0002328 ;
        obo:IAO_0000115     "A relation that holds between elements of a musculoskeletal system or its analogs." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." .

obo:RO_0002441  a               owl:ObjectProperty ;
        rdfs:label              "commensually interacts with" ;
        rdfs:subPropertyOf      obo:RO_0002440 ;
        obo:IAO_0000115         "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ;
        obo:RO_0002561          obo:GO_0085031 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002356  a           owl:ObjectProperty ;
        rdfs:label          "results in specification of"@en ;
        rdfs:range          obo:CL_0000000 ;
        rdfs:subPropertyOf  obo:RO_0002295 ;
        obo:IAO_0000115     "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.geneontology.org/GO.doc.development.shtml#fate"^^xsd:anyURI .

obo:RO_0002230  rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002622  a           owl:ObjectProperty ;
        rdfs:label          "visits flowers of" ;
        rdfs:subPropertyOf  obo:RO_0002618 ;
        owl:inverseOf       obo:RO_0002623 .

obo:RO_0002537  a           owl:AnnotationProperty ;
        rdfs:label          "has start time value" ;
        rdfs:subPropertyOf  obo:RO_0002535 .

obo:RO_0002411  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "causally upstream of"@en ;
        rdfs:subPropertyOf  obo:RO_0002418 , obo:BFO_0000063 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002326  a           owl:ObjectProperty ;
        rdfs:label          "contributes to"@en ;
        rdfs:subPropertyOf  obo:RO_0002329 , obo:RO_0002216 ;
        obo:IAO_0000112     "ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity." , "eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to \"ribosome binding\". And all three are part_of an eIF2 complex" , "Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity." ;
        obo:IAO_0000116     "We would like to say\n\nif and only if\n exists c', p'\n  c part_of c' and c' capable_of p\n   and\n  c capable_of p' and p' part_of p\nthen\n c contributes_to p\n\nHowever, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to" ;
        obo:IAO_0000232     "In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. " .

obo:RO_0002200  a           owl:ObjectProperty ;
        rdfs:domain         []  ;
        rdfs:label          "has phenotype"@en ;
        rdfs:range          obo:UPHENO_0001001 ;
        rdfs:subPropertyOf  owl:topObjectProperty ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ;
        obo:IAO_0000117     "Chris Mungall"@en ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002201 .

obo:RO_0002115  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type III terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ;
        rdfs:label             "synapsed_by_via_type_III_bouton"@en ;
        rdfs:subPropertyOf     obo:RO_0002103 ;
        obo:IAO_0000115        "Relation between a muscle and a motor neuron that synapses to it via a type III bouton.\n" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0097467 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002507  a           owl:ObjectProperty ;
        rdfs:domain         obo:RO_0002577 ;
        rdfs:label          "determined by" ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:RO_0002559 , obo:RO_0002509 , obo:BFO_0000050 ;
        obo:IAO_0000112     "A coral reef environment is determined by a particular coral reef" ;
        obo:IAO_0000115     "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." ;
        obo:IAO_0000116     "The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/24330602> ;
        obo:IAO_0000589     "determined by (system to material entity)" ;
        dc:creator          "Pier Buttigieg" , "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002508 .

obo:RO_0009001  a        owl:IrreflexiveProperty , owl:ObjectProperty ;
        rdfs:domain      obo:BFO_0000040 ;
        rdfs:label       "has substance added"@en ;
        rdfs:range       obo:BFO_0000040 ;
        obo:IAO_0000112  "muffin 'has substance added' some 'baking soda'"@en ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "\"has substance added\" is a relation existing between a (physical) entity and a substance in which the entity has had the substance added to it at some point in time."@en ;
        obo:IAO_0000116  "The relation X 'has substance added' some Y doesn't imply that X still has Y in any detectable fashion subsequent to the addition. Water in dehydrated food or ice cubes are examples, as is food that undergoes chemical transformation. This definition should encompass recipe ingredients."@en ;
        obo:IAO_0000117  "Damion Dooley" .

obo:RO_0002091  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002483  a   owl:AnnotationProperty ;
        rdfs:label  "inherited annotation property" .

obo:RO_0004007  a                owl:ObjectProperty ;
        rdfs:label               "has primary input or output" ;
        rdfs:subPropertyOf       obo:RO_0000057 ;
        obo:IAO_0000115          "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-12-13T11:26:17Z"^^xsd:dateTime .

obo:RO_0002579  a           owl:AnnotationProperty ;
        rdfs:label          "is indirect form of" ;
        rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y" ;
        dc:creator          "Chris Mungall" .

obo:RO_0002453  a           owl:ObjectProperty ;
        rdfs:label          "host of" ;
        rdfs:subPropertyOf  obo:RO_0002440 ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "The term host is usually used for the larger (macro) of the two members of a symbiosis (GO)" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002242  a           owl:ObjectProperty ;
        rdfs:label          "has exposure route" ;
        rdfs:subPropertyOf  obo:RO_0002244 ;
        obo:IAO_0000115     "A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor" ;
        obo:IAO_0000119     "ExO:0000055" .

obo:RO_0002634  a                    owl:ObjectProperty ;
        rdfs:label                   "endoparasite of" ;
        rdfs:subPropertyOf           obo:RO_0002444 ;
        obo:IAO_0000119              "A sub-relation of parasite-of in which the parasite lives inside the host, beneath the integumental system" ;
        obo:IAO_0000119              <https://en.wikipedia.org/wiki/Parasitism#Types> ;
        oboInOwl1:hasRelatedSynonym  "lives inside of" ;
        owl:inverseOf                obo:RO_0002635 .

obo:RO_0002157  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label          "has derived by descendant" ;
        rdfs:subPropertyOf  obo:RO_0002320 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of derived by descent from" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002549  a           owl:AnnotationProperty ;
        rdfs:label          "start, weeks post birth" ;
        rdfs:subPropertyOf  obo:RO_0002537 .

obo:RO_0002423  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion on an annotation property"@en ;
        rdfs:subPropertyOf  obo:RO_0002421 .

obo:RO_0002338  a               owl:ObjectProperty ;
        rdfs:label              "has target start location"@en ;
        rdfs:subPropertyOf      obo:RO_0002344 ;
        obo:IAO_0000115         "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0003002  a           owl:ObjectProperty ;
        rdfs:label          "represses expression of" ;
        rdfs:subPropertyOf  obo:RO_0002449 ;
        obo:IAO_0000115     "Holds between protein a (a transcription factor) and DNA element b if and only if a diminishes the process of transcription of b." ;
        obo:IAO_0000116     "Logical axioms to be added after the relevant branch of GO is MIREOTed in" .

obo:RO_0002212  a               owl:ObjectProperty ;
        rdfs:label              "negatively regulates"@en ;
        rdfs:subPropertyOf      obo:RO_0002305 , obo:RO_0002211 ;
        obo:IAO_0000115         "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ;
        obo:IAO_0000117         "Chris Mungall"@en ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589         "negatively regulates (process to process)" ;
        obo:RO_0004050          obo:RO_0002211 ;
        owl:inverseOf           obo:RO_0002335 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002604  a           owl:AnnotationProperty ;
        rdfs:label          "is opposite of" ;
        rdfs:subPropertyOf  obo:RO_0002602 ;
        obo:IAO_0000112     "'anterior end of organism' is-opposite-of 'posterior end of organism'" , "'increase in temperature' is-opposite-of 'decrease in temperature'" ;
        obo:IAO_0000115     "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." .

obo:RO_0004049  a                owl:AnnotationProperty ;
        rdfs:label               "is positive form of" ;
        rdfs:subPropertyOf       obo:RO_0004048 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-03-14T00:03:16Z"^^xsd:dateTime .

obo:RO_0001000  obo:IAO_0000232  "This relation is taken from the RO2005 version of RO. It may be obsoleted and replaced by relations with different definitions. See also the 'develops from' family of relations." ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002519  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "is end sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002525 ;
        obo:IAO_0000115        "inverse of has end sequence" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000118        "ends" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        oboInOwl1:inSubset     obo:RO_0002259 .

obo:RO_0002001  a        owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label       "aligned with"@en ;
        obo:IAO_0000114  obo:IAO_0000125 ;
        obo:IAO_0000116  "May be obsoleted, see https://github.com/oborel/obo-relations/issues/260" ;
        obo:IAO_0000117  "David Osumi-Sutherland" ;
        obo:RO_0001900   obo:RO_0001901 .

obo:RO_0002580  a           owl:AnnotationProperty ;
        rdfs:label          "logical macro assertion on an axiom" ;
        rdfs:subPropertyOf  obo:RO_0002416 .

obo:RO_0002495  a           owl:ObjectProperty ;
        rdfs:label          "immediate transformation of" ;
        rdfs:subPropertyOf  obo:RO_0002494 , obo:RO_0002207 ;
        obo:IAO_0000115     "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:RO_0002575      obo:RO_0002494 .

obo:RO_0003309  a           owl:ObjectProperty ;
        rdfs:label          "exacerbates condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003305 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." .

obo:RO_0004019  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease has basis in" ;
        rdfs:subPropertyOf       obo:RO_0004023 , obo:RO_0004017 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:26:47Z"^^xsd:dateTime .

obo:RO_0002550  a           owl:AnnotationProperty ;
        rdfs:label          "end, weeks post birth" ;
        rdfs:subPropertyOf  obo:RO_0002538 .

obo:RO_0002465  a           owl:ObjectProperty ;
        rdfs:label          "is symbiosis" ;
        rdfs:subPropertyOf  obo:RO_0002563 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002254  a               owl:ObjectProperty ;
        rdfs:domain             obo:CARO_0000000 ;
        rdfs:label              "has developmental contribution from"@en ;
        rdfs:range              obo:CARO_0000000 ;
        rdfs:subPropertyOf      obo:RO_0002258 ;
        obo:IAO_0000112         "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x has developmental contribution from y iff x has some part z such that z develops from y"@en ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:inverseOf           obo:RO_0002255 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002520  a              owl:ObjectProperty ;
        rdfs:label             "is consecutive sequence of" ;
        rdfs:subPropertyOf     obo:RO_0002524 ;
        obo:IAO_0000115        "x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y." ;
        obo:IAO_0000116        "In the SO paper, this was defined as an instance-type relation" ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0004050  a                owl:AnnotationProperty ;
        rdfs:label               "is negative form of" ;
        rdfs:subPropertyOf       obo:RO_0004048 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-03-14T00:03:24Z"^^xsd:dateTime .

obo:RO_0002435  a           owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label          "genetically interacts with" ;
        rdfs:seeAlso        "http://purl.obolibrary.org/obo/MI_0208"^^xsd:anyURI ;
        rdfs:seeAlso        obo:ECO_0000316 ;
        rdfs:subPropertyOf  obo:RO_0002434 ;
        obo:IAO_0000116     "An interaction that holds between two genetic entities (genes, alleles) through some genetic interaction (e.g. epistasis)" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0003310  a           owl:ObjectProperty ;
        rdfs:label          "condition ameliorated by"@en ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." .

obo:RO_0002224  rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002616  a        owl:ObjectProperty ;
        rdfs:label       "related via evidence or inference to" ;
        obo:IAO_0000232  "Do not use this relation directly. It is a grouping relation." .

obo:RO_0008501  a           owl:ObjectProperty ;
        rdfs:label          "epiphyte of" ;
        rdfs:subPropertyOf  obo:RO_0002440 ;
        obo:IAO_0000115     "An interaction relationship wherein a plant or algae is living on the outside surface of another plant." ;
        obo:IAO_0000119     "https://en.wikipedia.org/wiki/Epiphyte" ;
        owl:inverseOf       obo:RO_0008502 .

obo:RO_0004020  a                owl:ObjectProperty ;
        rdfs:label               "disease has basis in dysfunction of" ;
        rdfs:range               obo:CARO_0000006 ;
        rdfs:subPropertyOf       obo:RO_0004019 ;
        obo:IAO_0000115          "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." ;
        obo:IAO_0000589          "disease has basis in dysfunction of (disease to anatomical structure)" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:29:32Z"^^xsd:dateTime .

obo:RO_0002592  a           owl:ObjectProperty ;
        rdfs:label          "results in organization of" ;
        rdfs:subPropertyOf  obo:RO_0040036 ;
        obo:IAO_0000115     "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" .

obo:RO_0002013  a                owl:ObjectProperty ;
        rdfs:label               "has regulatory component activity" ;
        rdfs:subPropertyOf       obo:RO_0002334 , obo:RO_0002017 ;
        obo:IAO_0000115          "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:30:46Z"^^xsd:dateTime .

obo:RO_0002405  a           owl:ObjectProperty ;
        rdfs:label          "immediately causally downstream of"@en ;
        rdfs:subPropertyOf  obo:RO_0002087 , obo:RO_0002404 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000117     "Chris Mungall" ;
        owl:inverseOf       obo:RO_0002412 .

obo:RO_0002381  a           owl:ObjectProperty ;
        rdfs:label          "main stem of"@en ;
        rdfs:subPropertyOf  obo:RO_0002375 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path." ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002109  a              owl:ObjectProperty ;
        rdfs:comment           "Expands to: has_part some ('presynaptic membrane' that part_of some ('synapse' that has_part some ('type Ib terminal button' that has_part some 'postsynaptic membrane' that part_of some ?Y)))))" ;
        rdfs:label             "synapsed_by_via_type_Ib_bouton"@en ;
        rdfs:subPropertyOf     obo:RO_0002103 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton." ;
        obo:IAO_0000117        "Marta Costa" , "David Osumi-Sutherland" ;
        obo:IAO_0000424        "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0061176 that BFO_0000051 some GO_0045211 that BFO_0000050 some ?Y)))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002296  a            owl:ObjectProperty ;
        rdfs:label           "results in development of"@en ;
        rdfs:subPropertyOf   obo:RO_0040036 , obo:RO_0002295 ;
        obo:IAO_0000112      "every flower development (GO:0009908) results in development of some flower (PO:0009046)"@en ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000115      "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000119      "http://www.geneontology.org/GO.doc.development.shtml"^^xsd:anyURI ;
        oboInOwl1:shorthand  "results_in_development_of" .

obo:RO_0002170  a               owl:ObjectProperty ;
        rdfs:domain             []  ;
        rdfs:label              "connected to"@en ;
        rdfs:range              []  ;
        rdfs:subPropertyOf      obo:RO_0002323 ;
        obo:IAO_0000112         "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ;
        obo:IAO_0000115         "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" ;
        obo:IAO_0000119         <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        owl:propertyChainAxiom  []  ;
        foaf:page               "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI , "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI .

obo:RO_0002562  a           owl:AnnotationProperty ;
        rdfs:label          "is relational form of process class" ;
        rdfs:subPropertyOf  obo:RO_0002594 ;
        obo:IAO_0000115     "R is the relational form of a process if and only if either (1) R is the symmetric relational form of a process or (2) R is the asymmetric relational form of a process" ;
        foaf:page           "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_0002085  a           owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:comment        "Previously had ID  http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point.  No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line.  Official ID now chosen from DOS ID range." ;
        rdfs:label          "encompasses"@en ;
        rdfs:subPropertyOf  obo:RO_0002088 ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        obo:IAO_0000118     "di" ;
        owl:inverseOf       obo:RO_0002092 .

obo:RO_0002477  a           owl:ObjectProperty ;
        rdfs:label          "child nucleus of in hermaphrodite" ;
        rdfs:subPropertyOf  obo:RO_0002476 ;
        obo:IAO_0000115     "A child nucleus relationship in which the cells are part of a hermaphroditic organism" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002532  a        owl:Class ;
        rdfs:label       "sequentially ordered entity" ;
        rdfs:subClassOf  []  ;
        obo:IAO_0000115  "Any entity that is ordered in discrete units along a linear axis." ;
        obo:IAO_0000117  "Chris Mungall" .

<urn:swrl#A>  a  swrl:Variable .

obo:RO_0002447  a               owl:ObjectProperty ;
        rdfs:label              "phosphorylates" ;
        rdfs:subPropertyOf      obo:RO_0002436 ;
        obo:IAO_0000116         "Axiomatization to GO to be added later" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." ;
        owl:propertyChainAxiom  []  .

obo:RO_0002321  a           owl:ObjectProperty ;
        rdfs:label          "ecologically related to"@en ;
        obo:IAO_0000115     "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" ;
        obo:IAO_0000116     "Awaiting class for domain/range constraint, see: https://github.com/OBOFoundry/Experimental-OBO-Core/issues/6" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving ecological interactions" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002236  a           owl:ObjectProperty ;
        rdfs:label          "root parasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host root (PO:0009005)" .

obo:RO_0002110  a               owl:ObjectProperty ;
        rdfs:domain             []  ;
        rdfs:label              "has postsynaptic terminal in"@en ;
        rdfs:subPropertyOf      obo:RO_0002130 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "@en ;
        obo:IAO_0000117         "Chris Mungall"@en , "David Osumi-Sutherland"@en ;
        obo:IAO_0000118         "synapsed in"@en ;
        obo:IAO_0000424         "http://purl.obolibrary.org/obo/BFO_0000051 some (\n   http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n      http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002502  a        owl:ObjectProperty ;
        rdfs:label       "depends on" ;
        rdfs:seeAlso     obo:BFO_0000169 ;
        obo:IAO_0000117  "Chris Mungall" .

obo:RO_0004032  a                owl:ObjectProperty ;
        rdfs:label               "acts upstream of or within, positive effect" ;
        rdfs:seeAlso             <http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect> ;
        rdfs:subPropertyOf       obo:RO_0002264 ;
        obo:RO_0004049           obo:RO_0002264 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-01-26T23:49:30Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002025  a                owl:ObjectProperty , owl:FunctionalProperty ;
        rdfs:comment             "This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations." ;
        rdfs:label               "has effector activity" ;
        rdfs:subPropertyOf       obo:RO_0002211 , obo:RO_0002017 ;
        obo:IAO_0000115          "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-09-22T14:14:36Z"^^xsd:dateTime .

obo:RO_0002206  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000002 ;
        rdfs:domain             []  ;
        rdfs:label              "expressed in"@en ;
        rdfs:range              obo:CARO_0000006 ;
        rdfs:subPropertyOf      obo:RO_0002330 ;
        obo:IAO_0000112         "'neural crest cell'  SubClassOf expresses some 'Wnt1 gene'" ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ;
        obo:IAO_0000117         "Chris Mungall"@en ;
        owl:inverseOf           obo:RO_0002292 ;
        owl:propertyChainAxiom  []  .

obo:RO_0004002  a                owl:ObjectProperty ;
        rdfs:label               "has material basis in loss of function germline mutation in" ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:45:37Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004012 .

obo:RO_0002574  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0001010 ;
        rdfs:label          "participates in a biotic-biotic interaction with" ;
        rdfs:range          obo:CARO_0001010 ;
        rdfs:seeAlso        <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
        rdfs:subPropertyOf  obo:RO_0002437 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002489  a           owl:ObjectProperty ;
        rdfs:label          "existence starts with" ;
        rdfs:subPropertyOf  obo:RO_0002488 ;
        obo:IAO_0000115     "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002544  a           owl:AnnotationProperty ;
        rdfs:label          "end, months post birth" ;
        rdfs:subPropertyOf  obo:RO_0002538 ;
        obo:IAO_0000115     "Count of number of months intervening between the end of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 1 for this property, and the period during which the child is one month old has the value 2" .

obo:RO_0002459  a           owl:ObjectProperty ;
        rdfs:label          "is vector for" ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        obo:IAO_0000112     "Anopheles is a vector for Plasmodium" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "a is a vector for b if a carries and transmits an infectious pathogen b into another living organism" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002460 .

obo:RO_0002333  a           owl:ObjectProperty ;
        rdfs:label          "enabled by"@en ;
        rdfs:subPropertyOf  obo:RO_0002328 , obo:RO_0000057 ;
        obo:IAO_0000115     "inverse of enables" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002248  a                    owl:ObjectProperty ;
        rdfs:domain                  obo:BFO_0000040 ;
        rdfs:label                   "has active ingredient" ;
        rdfs:range                   obo:BFO_0000040 ;
        rdfs:subPropertyOf           obo:BFO_0000051 ;
        obo:IAO_0000112              "Any portion of roundup 'has active ingredient' some glyphosate" ;
        obo:IAO_0000115              "A relationship that holds between a substance and a chemical entity, if the chemical entity is part of the substance, and the chemical entity forms the biologically active component of the substance." ;
        oboInOwl1:hasExactSynonym    "has active substance" ;
        oboInOwl1:hasRelatedSynonym  "has active pharmaceutical ingredient" ;
        owl:inverseOf                obo:RO_0002249 .

obo:RO_0002514  a              owl:ObjectProperty ;
        rdfs:domain            obo:RO_0002532 ;
        rdfs:label             "sequentially related to" ;
        rdfs:range             obo:RO_0002532 ;
        obo:IAO_0000115        "A relation that holds between two entities that have the property of being sequences or having sequences. " ;
        obo:IAO_0000117        "Chris Mungall" ;
        obo:IAO_0000119        "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
        obo:IAO_0000232        "The domain and range of this relation include entities such as: information-bearing macromolecules such as DNA, or regions of these molecules; abstract information entities encoded as a linear sequence including text, abstract DNA sequences; Sequence features, entities that have a sequence or sequences. Note that these entities are not necessarily contiguous - for example, the mereological sum of exons on a genome of a particular gene." , "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving cause and effect." ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0000301  a              owl:ObjectProperty , owl:TransitiveProperty ;
        rdfs:label             "upstream in neural circuit with"@en ;
        rdfs:subPropertyOf     obo:RO_0000300 ;
        obo:IAO_0000114        obo:IAO_0000125 ;
        obo:IAO_0000115        "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next."@en ;
        obo:IAO_0000117        "David Osumi-Sutherland"@en ;
        obo:IAO_0000426        "(forall (?x ?y) \n\t(iff \n\t\t(upstream_neural_circuit_path  ?x ?y)\n\t\t(and\n\t\t\t(\"neuron ; CL_0000540\" ?x)\n\t\t\t(\"neuron ; CL_0000540\" ?y)\n\t\t\t(synapsed_to ?x ?y))))\n\n\n(forall (...s ?x ?y ?z) \n\t(iff \n\t\t(upstream_neural_circuit_path ...s ?x ?y ?z )\n\t\t(and\n\t\t\t(upstream_neural_circuit_path ...s ?x ?y)\n\t\t\t(\"neuron ; CL_0000540\" ?z)\n\t\t\t(synapsed_to ?y ?z))))\n\t\t\t\n(forall (?x ?y) \n\t(iff \n\t\t(upstream_in_neural_circuit_with ?x ?y)\n\t\t(exists (...s)\n\t\t\t(upstream_neural_circuit_path  ?x ...s ?y))))" ;
        obo:RO_0001900         obo:RO_0001901 ;
        cito:citesAsAuthority  <http://www.ncbi.nlm.nih.gov/pubmed/22402613> .

obo:RO_0002429  a               owl:ObjectProperty ;
        rdfs:label              "involved in positive regulation of" ;
        rdfs:subPropertyOf      obo:RO_0002428 ;
        obo:IAO_0000115         "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:RO_0004049          obo:RO_0002428 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002303  a           owl:ObjectProperty ;
        rdfs:comment        "A population of xs will possess adaptations (either evolved naturally or via artifical selection) which permit it to exist and grow in y." ;
        rdfs:domain         obo:CARO_0001010 ;
        rdfs:label          "has habitat"@en ;
        rdfs:range          obo:ENVO_01000254 ;
        rdfs:subPropertyOf  obo:RO_0002321 ;
        obo:IAO_0000112     "Hydrozoa (NCBITaxon_6074) SubClassOf 'has habitat' some 'Hydrozoa habitat'\nwhere\n'Hydrozoa habitat' SubClassOf overlaps some ('marine environment' (ENVO_00000569) and 'freshwater environment' (ENVO_01000306) and 'wetland' (ENVO_00000043)) and 'has part' some (freshwater (ENVO_00002011) or 'sea water' (ENVO_00002149)) -- http://eol.org/pages/1795/overview" ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs." ;
        obo:IAO_0000117     "Pier Buttigieg" ;
        obo:IAO_0000118     "adapted for living in" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002490  a           owl:ObjectProperty ;
        rdfs:comment        "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label          "existence overlaps" ;
        rdfs:subPropertyOf  obo:RO_0002487 ;
        obo:IAO_0000115     "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0003304  a           owl:ObjectProperty ;
        rdfs:label          "contributes to condition"@en ;
        rdfs:subPropertyOf  obo:RO_0003302 ;
        obo:IAO_0000115     "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition." .

obo:RO_0002218  a           owl:ObjectProperty ;
        rdfs:label          "obsolete has active participant" ;
        rdfs:subPropertyOf  obo:RO_0000057 ;
        obo:IAO_0000112     "'heart development' has active participant some Shh protein" ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x has participant y if and only if x realizes some active role that inheres in y" ;
        obo:IAO_0000116     "This may be obsoleted and replaced by the original 'has agent' relation" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "has agent" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:deprecated      true .

obo:RO_0004014  a                owl:ObjectProperty ;
        rdfs:label               "is causal somatic mutation in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317344> ;
        rdfs:subPropertyOf       obo:RO_0004010 ;
        obo:IAO_0000115          "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:57:07Z"^^xsd:dateTime .

obo:RO_0002007  a           owl:ObjectProperty ;
        rdfs:comment        "A relationship that applies between a continuant and its outer, bounding layer.  Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane." ;
        rdfs:domain         []  ;
        rdfs:label          "bounding layer of"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000115     "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" ;
        obo:IAO_0000117     "David Osumi-Sutherland" ;
        oboInOwl1:inSubset  subsets:ro-eco .

<urn:swrl#x>  a  swrl:Variable .

obo:RO_0002586  a           owl:ObjectProperty ;
        rdfs:label          "results in breakdown of" ;
        rdfs:subPropertyOf  obo:RO_0002233 ;
        obo:IAO_0000115     "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" .

obo:RO_0002460  a           owl:ObjectProperty ;
        rdfs:label          "has vector" ;
        rdfs:subPropertyOf  obo:RO_0002574 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

<urn:swrl#in>  a  swrl:Variable .

obo:RO_0002375  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000040 ;
        rdfs:label          "in branching relationship with"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:seeAlso        <http://purl.obolibrary.org/obo/ro/docs/branching_part_of.png> ;
        rdfs:subPropertyOf  obo:BFO_0000050 , obo:RO_0002323 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000232     "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)" , "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships" ;
        foaf:page           "https://github.com/obophenotype/uberon/issues/170"^^xsd:anyURI .

obo:RO_0002641  a           owl:ObjectProperty ;
        rdfs:label          "has intracellular endoparasite" ;
        rdfs:subPropertyOf  obo:RO_0002635 ;
        obo:IAO_0000115     "inverse of intracellular endoparasite of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002556  a           owl:ObjectProperty ;
        rdfs:label          "pathogen of" ;
        rdfs:subPropertyOf  obo:RO_0002454 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002557 .

obo:RO_0002430  a               owl:ObjectProperty ;
        rdfs:label              "involved in negative regulation of" ;
        rdfs:subPropertyOf      obo:RO_0002428 ;
        obo:IAO_0000115         "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:RO_0004050          obo:RO_0002428 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002345  a               owl:ObjectProperty ;
        rdfs:label              "exports"@en ;
        rdfs:subPropertyOf      obo:RO_0002020 ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002611  a           owl:AnnotationProperty ;
        rdfs:label          "evidential logical macro assertion on an axiom" ;
        rdfs:subPropertyOf  obo:RO_0002580 .

obo:GO_0048018  a  owl:Class .

obo:RO_0002134  a               owl:ObjectProperty ;
        rdfs:domain             obo:CARO_0001001 ;
        rdfs:label              "innervates"@en ;
        rdfs:subPropertyOf      owl:topObjectProperty ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."@en ;
        obo:IAO_0000117         "David Osumi-Sutherland"@en ;
        obo:IAO_0000424         "<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))" ;
        obo:RO_0001900          obo:RO_0001901 ;
        cito:citesAsAuthority   <http://www.ncbi.nlm.nih.gov/pubmed/22402613> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002526  a               owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label              "overlaps sequence of" ;
        rdfs:subPropertyOf      obo:RO_0002131 , obo:RO_0002514 ;
        obo:IAO_0000115         "x overlaps the sequence of x if and only if x has a subsequence z and z is a subsequence of y." ;
        obo:IAO_0000117         "Chris Mungall" ;
        cito:citesAsAuthority   <http://biorxiv.org/content/early/2014/06/27/006650.abstract> ;
        owl:propertyChainAxiom  []  .

obo:RO_0002400  a               owl:ObjectProperty ;
        rdfs:label              "has direct input"@en ;
        rdfs:subPropertyOf      obo:RO_0002233 ;
        obo:IAO_0000112         "'protein catabolic process' SubClassOf has_direct_input some protein" ;
        obo:IAO_0000114         obo:IAO_0000428 ;
        obo:IAO_0000115         "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "directly consumes" ;
        obo:IAO_0000232         "This is likely to be obsoleted. A candidate replacement would be a new relation 'has bound input' or 'has substrate'" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002315  a            owl:ObjectProperty ;
        rdfs:label           "results in acquisition of features of"@en ;
        rdfs:range           obo:CARO_0000003 ;
        rdfs:subPropertyOf   obo:RO_0002295 , obo:RO_0040036 ;
        obo:IAO_0000112      "an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast." ;
        obo:IAO_0000115      "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000119      "GOC:mtg_berkeley_2013" ;
        oboInOwl1:shorthand  "results_in_acquisition_of_features_of" .

obo:RO_0002019  a                owl:ObjectProperty ;
        rdfs:domain              obo:GO_0004872 ;
        rdfs:label               "has ligand" ;
        rdfs:subPropertyOf       obo:RO_0002233 ;
        obo:IAO_0000115          "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-07-19T17:30:36Z"^^xsd:dateTime .

obo:RO_0002291  a           owl:ObjectProperty ;
        rdfs:label          "ubiquitously expressed in"@en ;
        rdfs:subPropertyOf  obo:RO_0002206 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" ;
        obo:IAO_0000116     "Revisit this term after coordinating with SO/SOM. The domain of this relation should be a sequence, as an instance of a DNA molecule is only expressed in the cell of which it is a part." ;
        obo:IAO_0000117     "Chris Mungall" ;
        owl:inverseOf       obo:RO_0002293 .

obo:RO_0002104  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000006 ;
        rdfs:label          "has plasma membrane part"@en ;
        rdfs:range          obo:CARO_0000006 ;
        rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000112     "Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]"@en ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ;
        obo:IAO_0000117     "Chris Mungall"@en , "Alexander Diehl" , "Lindsay Cowell" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/19243617> ;
        obo:IAO_0000424     "<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0005886> and <http://purl.obolibrary.org/obo/BFO_0000051> some ?Y)" ;
        obo:RO_0001900      obo:RO_0001901 .

obo:RO_0004026  a                owl:ObjectProperty ;
        rdfs:domain              obo:OGMS_0000031 ;
        rdfs:label               "disease has location" ;
        rdfs:range               obo:BFO_0000004 ;
        rdfs:range               []  ;
        rdfs:subPropertyOf       obo:RO_0040035 ;
        obo:IAO_0000115          "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
        obo:IAO_0000116          "TODO: complete range axiom once more of CARO has been mireoted in to this ontology" ;
        obo:IAO_0000232          "This relation is intentionally very general, and covers isolated diseases, where the disease is realized as a process occurring in the location, and syndromic diseases, where one or more of the features may be present in that location. Thus any given disease can have multiple locations in the sense defined here." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T04:06:02Z"^^xsd:dateTime .

obo:RO_0001018  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000040 ;
        rdfs:label              "contained in"@en ;
        rdfs:range              obo:BFO_0000004 ;
        obo:IAO_0000111         "contained in"@en ;
        obo:IAO_0000116         "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." , "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation.    If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows:    c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):"@en , "Intended meaning:\ndomain: material entity\nrange: spatial region or site (immaterial continuant)\n        "@en ;
        obo:IAO_0000118         "contained_in"@en ;
        obo:RO_0001900          obo:RO_0001901 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:inverseOf           obo:RO_0001019 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002598  a               owl:ObjectProperty ;
        rdfs:label              "capable of positively regulating" ;
        rdfs:subPropertyOf      obo:RO_0002596 ;
        obo:IAO_0000112         "renin -> arteriolar smooth muscle contraction" ;
        obo:IAO_0000115         "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        owl:propertyChainAxiom  []  .

obo:RO_0008507  a           owl:ObjectProperty ;
        rdfs:label          "lays eggs on" ;
        rdfs:subPropertyOf  obo:RO_0002618 ;
        obo:IAO_0000115     "An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation." ;
        owl:inverseOf       obo:RO_0008508 .

obo:RO_0002472  a           owl:ObjectProperty ;
        rdfs:label          "is evidence for" ;
        rdfs:subPropertyOf  obo:RO_0002616 ;
        obo:IAO_0000115     "A relationship between a piece of evidence a and some entity b, where b is  an information content entity, material entity or process, and \nthe a supports either the existence of b, or the truth value of b." ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco ;
        owl:inverseOf       obo:RO_0002558 .

obo:IAO_0000232  a  owl:AnnotationProperty .

obo:RO_0002387  a           owl:ObjectProperty ;
        rdfs:label          "has potential to develop into"@en ;
        rdfs:subPropertyOf  obo:RO_0002384 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x has the potential to develop into y iff x develops into y or if x is capable of developing into y"@en ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002261  a  owl:ObjectProperty .

obo:RO_0002176  a           owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000004 ;
        rdfs:label          "connects"@en ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000112     "The M8 connects Glasgow and Edinburgh" , "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." ;
        obo:IAO_0000115     "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        foaf:page           "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern"^^xsd:anyURI , "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern"^^xsd:anyURI .

obo:RO_0002568  a           owl:ObjectProperty ;
        rdfs:label          "has muscle antagonist" ;
        rdfs:subPropertyOf  obo:RO_0002567 ;
        obo:IAO_0000115     "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     "Wikipedia:Antagonist_(muscle)" .

obo:RO_0002442  a               owl:ObjectProperty ;
        rdfs:label              "mutualistically interacts with" ;
        rdfs:subPropertyOf      obo:RO_0002440 ;
        obo:IAO_0000115         "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000119         "http://www.ncbi.nlm.nih.gov/pubmed/19278549"^^xsd:anyURI ;
        obo:RO_0002561          obo:GO_0085030 ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002357  a           owl:ObjectProperty ;
        rdfs:label          "results in developmental induction of"@en ;
        rdfs:subPropertyOf  obo:RO_0002295 ;
        obo:IAO_0000115     "p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c." ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002231  a               owl:ObjectProperty ;
        rdfs:domain             obo:BFO_0000015 ;
        rdfs:label              "has start location"@en ;
        rdfs:range              obo:BFO_0000004 ;
        rdfs:subPropertyOf      obo:RO_0002479 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "starts with process that occurs in" ;
        oboInOwl1:inSubset      subsets:ro-eco ;
        owl:propertyChainAxiom  []  .

obo:RO_0002623  a           owl:ObjectProperty ;
        rdfs:label          "has flowers visited by" ;
        rdfs:subPropertyOf  obo:RO_0002619 .

obo:BFO_0000060  owl:deprecated  true .

obo:RO_0002538  a           owl:AnnotationProperty ;
        rdfs:label          "has end time value" ;
        rdfs:subPropertyOf  obo:RO_0002535 .

obo:RO_0002020  a                owl:ObjectProperty ;
        rdfs:label               "transports" ;
        rdfs:subPropertyOf       obo:RO_0002313 ;
        obo:IAO_0000115          "Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-07-20T17:11:08Z"^^xsd:dateTime .

obo:RO_0002412  a           owl:ObjectProperty ;
        rdfs:label          "immediately causally upstream of"@en ;
        rdfs:subPropertyOf  obo:RO_0002411 , obo:RO_0002090 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:RO_0002575      obo:RO_0002411 .

obo:RO_0002327  a               owl:ObjectProperty ;
        rdfs:label              "enables"@en ;
        rdfs:subPropertyOf      obo:RO_0002215 ;
        obo:IAO_0000112         "a particular instances of akt-2 enables some instance of protein kinase activity" ;
        obo:IAO_0000117         "Chris Mungall" ;
        obo:IAO_0000118         "has" , "catalyzes" , "is executing" , "executes" , "is catalyzing" ;
        obo:IAO_0000232         "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." , "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." ;
        owl:inverseOf           obo:RO_0002333 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:GO_0004872  a  owl:Class .

obo:RO_0002201  a           owl:ObjectProperty , owl:FunctionalProperty ;
        rdfs:label          "phenotype of"@en ;
        rdfs:subPropertyOf  owl:topObjectProperty ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "inverse of has phenotype" ;
        obo:IAO_0000117     "Chris Mungall"@en ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002508  a           owl:ObjectProperty ;
        rdfs:label          "determines" ;
        rdfs:subPropertyOf  obo:RO_0002566 ;
        obo:IAO_0000115     "inverse of determined by" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000589     "determines (material entity to system)" ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002484  a           owl:AnnotationProperty ;
        rdfs:label          "curator guidance link" ;
        rdfs:subPropertyOf  obo:RO_0002483 ;
        obo:IAO_0000115     "Connects an ontology entity (class, property, etc) to a URL from which curator guidance can be obtained. This assertion is inherited in the same manner as functional annotations (e.g. for GO, over SubClassOf and part_of)" .

obo:RO_0002092  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0009002  a        owl:ObjectProperty , owl:IrreflexiveProperty ;
        rdfs:domain      obo:BFO_0000040 ;
        rdfs:label       "has substance removed"@en ;
        rdfs:range       obo:BFO_0000040 ;
        obo:IAO_0000112  "'egg white' 'has substance removed' some 'egg yolk'"@en ;
        obo:IAO_0000114  obo:IAO_0000428 ;
        obo:IAO_0000115  "\"has substance removed\" is a relation existing between two physical entities in which the first entity has had the second entity (a substance) removed from it at some point in time."@en ;
        obo:IAO_0000117  "Damion Dooley"@en .

obo:GO_0004842  rdfs:subClassOf  []  .

obo:RO_0004008  a                owl:ObjectProperty ;
        rdfs:label               "has primary output" ;
        rdfs:subPropertyOf       obo:RO_0004007 , obo:RO_0002234 ;
        obo:IAO_0000115          "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-12-13T11:26:32Z"^^xsd:dateTime .

obo:RO_0002454  a           owl:ObjectProperty ;
        rdfs:label          "has host" ;
        rdfs:seeAlso        "http://eol.org/schema/terms/hasHost" ;
        rdfs:subPropertyOf  obo:RO_0002440 ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002243  a           owl:ObjectProperty ;
        rdfs:label          "has exposure transport path" ;
        rdfs:subPropertyOf  obo:RO_0002244 ;
        obo:IAO_0000115     "A broad relationship between an exposure event or process and the course takes from the source to the target." ;
        obo:IAO_0000119     "http://purl.obolibrary.org/obo/ExO_0000004"^^xsd:anyURI .

obo:RO_0002635  a           owl:ObjectProperty ;
        rdfs:label          "has endoparasite" ;
        rdfs:subPropertyOf  obo:RO_0002445 .

obo:RO_0001900  rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." .

obo:RO_0002158  a               owl:TransitiveProperty , owl:SymmetricProperty , owl:ObjectProperty ;
        rdfs:comment            "VBO calls this homologous_to" ;
        rdfs:label              "shares ancestor with" ;
        rdfs:subPropertyOf      obo:RO_0002320 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." ;
        obo:IAO_0000232         "Consider obsoleting and merging with child relation, 'in homology relationship with'" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002424  a        owl:ObjectProperty ;
        rdfs:comment     "This is an exploratory relation" ;
        rdfs:label       "differs in"@en ;
        rdfs:seeAlso     "https://code.google.com/p/phenotype-ontologies/w/edit/PhenotypeModelCompetencyQuestions"^^xsd:anyURI ;
        obo:IAO_0000116  false ;
        obo:IAO_0000117  "Chris Mungall" .

obo:RO_0002339  a               owl:ObjectProperty ;
        rdfs:label              "has target end location"@en ;
        rdfs:subPropertyOf      obo:RO_0002344 ;
        obo:IAO_0000115         "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002213  a               owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:label              "positively regulates"@en ;
        rdfs:subPropertyOf      obo:RO_0002211 , obo:RO_0002304 ;
        obo:IAO_0000115         "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ;
        obo:IAO_0000117         "Chris Mungall"@en ;
        obo:IAO_0000119         <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589         "positively regulates (process to process)" ;
        obo:RO_0004049          obo:RO_0002211 ;
        owl:inverseOf           obo:RO_0002336 ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002605  a           owl:AnnotationProperty ;
        rdfs:label          "is indistinguishable from" ;
        rdfs:subPropertyOf  obo:RO_0002603 ;
        obo:IAO_0000115     "x is indistinguishable from y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." .

obo:RO_0001001  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002581  a           owl:AnnotationProperty ;
        rdfs:label          "is a defining property chain axiom" ;
        rdfs:subPropertyOf  obo:RO_0002580 ;
        obo:IAO_0000115     "If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL" .

obo:RO_0002002  rdfs:subPropertyOf  obo:RO_0002323 ;
        obo:IAO_0000117     "David Osumi-Sutherland" .

obo:RO_0003003  a           owl:ObjectProperty ;
        rdfs:label          "increases expression of" ;
        rdfs:subPropertyOf  obo:RO_0002450 ;
        obo:IAO_0000115     "Holds between protein a (a transcription factor) and DNA element b if and only if a activates the process of transcription of b." ;
        obo:IAO_0000116     "Logical axioms to be added after the relevant branch of GO is MIREOTed in" .

obo:RO_0002496  a               owl:ObjectProperty ;
        rdfs:comment            "The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription." ;
        rdfs:label              "existence starts during or after" ;
        rdfs:subPropertyOf      obo:RO_0002487 ;
        obo:IAO_0000115         "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  ;
        owl:propertyChainAxiom  []  .

obo:RO_0002309  a                owl:ObjectProperty ;
        rdfs:label               "has exposure stimulus" ;
        rdfs:subPropertyOf       obo:RO_0002244 ;
        obo:IAO_0000115          "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." ;
        dc:contributor           "Austin Meier" , "Marie Angelique Laporte" , "Chris Mungall" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-06-05T17:35:04Z"^^xsd:dateTime .

obo:RO_0002285  a           owl:ObjectProperty ;
        rdfs:label          "developmentally replaces"@en ;
        rdfs:subPropertyOf  obo:RO_0002258 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" ;
        obo:IAO_0000116     "This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "replaces" .

obo:RO_0002551  a           owl:IrreflexiveProperty , owl:ObjectProperty , owl:AsymmetricProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "has skeleton" ;
        rdfs:range          obo:CARO_0000006 ;
        rdfs:subPropertyOf  obo:BFO_0000051 ;
        obo:IAO_0000112     "Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'" ;
        obo:IAO_0000115     "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "has supporting framework" ;
        obo:IAO_0000232     "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." ;
        owl:inverseOf       obo:RO_0002576 .

obo:RO_0002466  a           owl:ObjectProperty ;
        rdfs:label          "is commensalism" ;
        rdfs:subPropertyOf  obo:RO_0002465 ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002340  a               owl:ObjectProperty ;
        rdfs:label              "imports"@en ;
        rdfs:subPropertyOf      obo:RO_0002020 ;
        obo:IAO_0000115         "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s." ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002255  a               owl:ObjectProperty ;
        rdfs:label              "developmentally contributes to"@en ;
        rdfs:subPropertyOf      obo:RO_0002385 , obo:RO_0002286 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "inverse of has developmental contribution from" ;
        obo:IAO_0000117         "Chris Mungall" ;
        oboInOwl1:inSubset      obo:RO_0002259 ;
        owl:propertyChainAxiom  []  .

obo:RO_0002521  a              owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label             "is sequentially aligned with" ;
        rdfs:subPropertyOf     obo:RO_0002514 ;
        obo:IAO_0000112        "Human Shh and Mouse Shh are sequentially aligned, by cirtue of the fact that they derive from the same ancestral sequence." ;
        obo:IAO_0000115        "x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering" ;
        obo:IAO_0000117        "Chris Mungall" ;
        cito:citesAsAuthority  <http://biorxiv.org/content/early/2014/06/27/006650.abstract> .

obo:RO_0002436  a           owl:ObjectProperty , owl:SymmetricProperty ;
        rdfs:label          "molecularly interacts with" ;
        rdfs:seeAlso        "http://purl.obolibrary.org/obo/MI_0915"^^xsd:anyURI ;
        rdfs:seeAlso        obo:ECO_0000353 ;
        rdfs:subPropertyOf  obo:RO_0002434 ;
        obo:IAO_0000115     "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "binds" , "molecularly binds with" .

obo:RO_0002310  a                owl:Class ;
        rdfs:label               "exposure event or process" ;
        rdfs:seeAlso             "https://github.com/oborel/obo-relations/pull/173"^^xsd:anyURI ;
        rdfs:subClassOf          obo:BFO_0000015 ;
        obo:IAO_0000112          "An exposure event in which a human is exposed to particulate matter in the air. Here the exposure stimulus/stress is the particulate matter, the receptor is the airways and lungs of the human," , "An exposure event in which a plant is provided with fertilizer. The exposure receptor is the root system of the plant, the stimulus is the fertilizing chemical, the route is via the soil, possibly mediated by symbotic microbes."^^xsd:anyURI ;
        obo:IAO_0000115          "A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism." ;
        obo:IAO_0000116          "This class is intended as a grouping for various domain and species-specific exposure classes. The ExO class http://purl.obolibrary.org/obo/ExO_0000002 'exposure event' assumes that all exposures involve stressors, which limits the applicability of this class to 'positive' exposures, e.g. exposing a plant to beneficial growing conditions." ;
        dc:creator               "Chris Mungall" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-06-05T17:55:39Z"^^xsd:dateTime .

obo:RO_0003311  a           owl:ObjectProperty ;
        rdfs:label          "condition exacerbated by"@en ;
        rdfs:subPropertyOf  obo:RO_0002410 ;
        obo:IAO_0000115     "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." .

dc:description  a  owl:AnnotationProperty .

obo:RO_0002225  a               owl:ObjectProperty ;
        rdfs:label              "develops from part of"@en ;
        rdfs:subPropertyOf      obo:RO_0002202 ;
        obo:IAO_0000114         obo:IAO_0000125 ;
        obo:IAO_0000115         "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" ;
        obo:IAO_0000117         "Chris Mungall" ;
        owl:propertyChainAxiom  []  .

obo:RO_0002617  a           owl:AnnotationProperty ;
        rdfs:label          "is representative IRI for equivalence set" ;
        rdfs:seeAlso        "OWLAPI Reasoner documentation for representativeElement, which follows a similar idea, but selects an arbitrary member" ;
        rdfs:subPropertyOf  obo:RO_0002601 ;
        obo:IAO_0000112     "In the context of a particular project, the IRI with CURIE NCBIGene:64327 (which in this example denotes a class) is considered to be representative. This means that if we have equivalent classes with IRIs OMIM:605522, ENSEMBL:ENSG00000105983, HGNC:13243 forming an equivalence set, the NCBIGene is considered the representative member IRI. Depending on the policies of the project, the classes may be merged, or the NCBIGene IRI may be chosen as the default in a user interface context." ;
        obo:IAO_0000115     "this property relates an IRI to the xsd boolean value \"True\" if the IRI is intended to be the representative IRI for a collection of classes that are mutually equivalent." ;
        obo:IAO_0000232     "If it is necessary to make the context explicit, an axiom annotation can be added to the annotation assertion" .

obo:RO_0008502  a           owl:ObjectProperty ;
        rdfs:label          "has epiphyte" ;
        rdfs:subPropertyOf  obo:RO_0002440 ;
        obo:IAO_0000115     "inverse of epiphyte of" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002593  a           owl:ObjectProperty ;
        rdfs:label          "existence ends at point" ;
        rdfs:subPropertyOf  obo:RO_0002487 ;
        obo:IAO_0000115     "x existence starts at point y if and only if the time point at which x starts is equivalent to the time point at which y ends." .

obo:RO_0004021  a                owl:ObjectProperty ;
        rdfs:label               "disease has basis in disruption of" ;
        rdfs:range               obo:BFO_0000015 ;
        rdfs:subPropertyOf       obo:RO_0004019 ;
        obo:IAO_0000115          "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." ;
        obo:IAO_0000589          "disease has basis in disruption of (disease to process)" ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T03:37:52Z"^^xsd:dateTime .

obo:RO_0002014  a                owl:ObjectProperty ;
        rdfs:comment             "By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'." ;
        rdfs:label               "has negative regulatory component activity" ;
        rdfs:subPropertyOf       obo:RO_0002335 , obo:RO_0002013 ;
        obo:IAO_0000115          "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-05-24T09:31:01Z"^^xsd:dateTime .

obo:RO_0002406  a           owl:ObjectProperty ;
        rdfs:label          "directly activates"@en ;
        rdfs:subPropertyOf  obo:RO_0002629 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "directly positively regulates" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "directly activates (process to process)" .

obo:RO_0002382  a           owl:ObjectProperty ;
        rdfs:label          "proper distributary of"@en ;
        rdfs:subPropertyOf  obo:RO_0002377 ;
        obo:IAO_0000114     obo:IAO_0000428 ;
        obo:IAO_0000115     "x proper_distributary_of y iff x distributary_of y and x does not flow back into y" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002297  a            owl:ObjectProperty ;
        rdfs:label           "results in formation of"@en ;
        rdfs:subPropertyOf   obo:RO_0002295 , obo:RO_0002234 ;
        obo:IAO_0000112      "an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists." , "every \"endocardial cushion formation\" (GO:0003272) results_in_formation_of some \"endocardial cushion\" (UBERON:0002062)"@en ;
        obo:IAO_0000114      obo:IAO_0000125 ;
        obo:IAO_0000117      "Chris Mungall" ;
        obo:IAO_0000119      "GOC:mtg_berkeley_2013" ;
        oboInOwl1:shorthand  "results_in_formation_of" ;
        owl:inverseOf        obo:RO_0002354 .

obo:RO_0010001  a                  owl:ObjectProperty ;
        rdfs:domain                obo:BFO_0000031 ;
        rdfs:label                 "generically depends on" ;
        rdfs:range                 obo:BFO_0000004 ;
        obo:IAO_0000112            "The score of a symphony g-depends on a copy of the score." , "The novel *War and Peace* generically depends on this copy of the novel." , "The pattern shared by chess boards generically depends on any chess board." , "Genetic information generically depend on molecules of DNA." , "This pdf file generically depends on this server." ;
        obo:IAO_0000115            "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." ;
        obo:IAO_0000119            "[072-ISO]" ;
        oboInOwl1:hasExactSynonym  "g-depends on" ;
        owl:inverseOf              obo:RO_0010002 ;
        owl:propertyChainAxiom     []  .

obo:RO_0002171  a           owl:AnnotationProperty ;
        rdfs:label          "mutually spatially disjoint with"@en ;
        rdfs:seeAlso        obo:RO_0002163 ;
        rdfs:subPropertyOf  obo:RO_0002420 ;
        obo:IAO_0000115     "A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B." ;
        obo:IAO_0000118     "non-overlapping with" , "shares no parts with" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/22293552> ;
        obo:IAO_0000425     "Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: (BFO_0000050 some ?X) and (BFO_0000050 some ?Y)" ;
        foaf:page           "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern"^^xsd:anyURI .

obo:RO_0002563  a           owl:ObjectProperty ;
        rdfs:label          "interaction relation helper property" ;
        rdfs:seeAlso        <http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29> ;
        rdfs:subPropertyOf  obo:RO_0002464 ;
        obo:IAO_0000117     "Chris Mungall" ;
        foaf:page           "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_HOM0000000  obo:IAO_0000116  "TODO: Add homeomorphy axiom" ;
        obo:RO_0040042   obo:BFO_0000003 , obo:BFO_0000002 .

obo:RO_0002086  oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002478  a           owl:ObjectProperty ;
        rdfs:label          "child nucleus of in male" ;
        rdfs:subPropertyOf  obo:RO_0002476 ;
        obo:IAO_0000115     "A child nucleus relationship in which the cells are part of a male organism" ;
        obo:IAO_0000117     "Chris Mungall" .

obo:RO_0002352  a           owl:ObjectProperty ;
        rdfs:label          "input of"@en ;
        rdfs:subPropertyOf  obo:RO_0000056 , obo:RO_0002328 ;
        obo:IAO_0000115     "inverse of has input" ;
        obo:IAO_0000117     "Chris Mungall" ;
        oboInOwl1:inSubset  obo:RO_0002259 , subsets:ro-eco .

obo:RO_0002533  a        owl:Class ;
        rdfs:label       "sequence atomic unit" ;
        rdfs:subClassOf  obo:RO_0002532 ;
        obo:IAO_0000115  "Any individual unit of a collection of like units arranged in a linear order" ;
        obo:IAO_0000117  "Chris Mungall" ;
        obo:IAO_0000232  "An individual unit can be a molecular entity such as a base pair, or an abstract entity, such as the abstraction of a base pair." .

<urn:swrl#B>  a  swrl:Variable .

obo:RO_0002448  a                  owl:ObjectProperty ;
        rdfs:label                 "activity directly regulates activity of" ;
        rdfs:subPropertyOf         obo:RO_0002436 , obo:RO_0002566 ;
        obo:IAO_0000115            "Holds between molecular entities A and B where A can physically interact with B and in doing so regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A regulates the kinase activity of B." ;
        obo:IAO_0000117            "Chris Mungall" ;
        oboInOwl1:hasExactSynonym  "molecularly controls" ;
        owl:propertyChainAxiom     []  .

obo:RO_0002322  a           owl:ObjectProperty ;
        rdfs:label          "confers advantage in"@en ;
        rdfs:range          obo:ENVO_01000254 ;
        rdfs:subPropertyOf  obo:RO_0002321 ;
        obo:IAO_0000116     "An experimental relation currently used to connect a feature possessed by an organism (e.g. anatomical structure, biological process, phenotype or quality) to a habitat or environment in which that feature is well suited, adapted or provides a reproductive advantage for the organism. For example, fins to an aquatic environment. Usually this will mean that the structure is adapted for this environment, but we avoid saying this directly - primitive forms of the structure may not have evolved specifically for that environment (for example, early wings were not necessarily adapted for an aerial environment). Note also that this is a statement about the general class of structures - not every instance of a limb need confer an advantage for a terrestrial environment, e.g. if the limb is vestigial." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000118     "adapted for" ;
        oboInOwl1:inSubset  subsets:ro-eco .

obo:RO_0002237  a           owl:ObjectProperty ;
        rdfs:label          "hemiparasite of" ;
        rdfs:subPropertyOf  obo:RO_0002444 ;
        obo:IAO_0000115     "A sub-relation of parasite-of in which the parasite is a plant, and the parasite is parasitic under natural conditions and is also photosynthetic to some degree. Hemiparasites may just obtain water and mineral nutrients from the host plant. Many obtain at least part of their organic nutrients from the host as well." .

obo:RO_0002629  a           owl:ObjectProperty ;
        rdfs:label          "directly positively regulates" ;
        rdfs:subPropertyOf  obo:RO_0002213 , obo:RO_0002578 ;
        obo:IAO_0000115     "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "directly positively regulates (process to process)" ;
        obo:RO_0004049      obo:RO_0002578 .

obo:RO_0002111  a           owl:ObjectProperty ;
        rdfs:domain         obo:CARO_0000003 ;
        rdfs:label          "releases neurotransmitter"@en ;
        rdfs:range          obo:BFO_0000040 ;
        rdfs:subPropertyOf  owl:topObjectProperty ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000118     "has neurotransmitter" .

obo:RO_0002503  a           owl:ObjectProperty ;
        rdfs:label          "towards" ;
        rdfs:subPropertyOf  obo:RO_0002502 ;
        obo:IAO_0000115     "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" ;
        obo:IAO_0000116     "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000119     <http://www.ncbi.nlm.nih.gov/pubmed/20064205> .

obo:RO_0004033  a                owl:ObjectProperty ;
        rdfs:label               "acts upstream of or within, negative effect" ;
        rdfs:subPropertyOf       obo:RO_0002264 ;
        obo:RO_0004050           obo:RO_0002264 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-01-26T23:49:51Z"^^xsd:dateTime ;
        owl:propertyChainAxiom   []  .

obo:RO_0002026  a                owl:ObjectProperty ;
        rdfs:domain              foaf:image ;
        rdfs:label               "in register with"@en ;
        rdfs:range               foaf:image ;
        rdfs:subPropertyOf       obo:RO_0002323 ;
        obo:IAO_0000115          "A relationship that holds between two images, A and B, where:\nA depicts X;\nB depicts Y;\nX and Y are both of type T'\nC is a 2 layer image consiting of layers A and B;\nA and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other.\nNote: A and B may be 2D or 3D.\nExamples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software." ;
        oboInOwl1:created_by     "dos" ;
        oboInOwl1:creation_date  "2017-12-07T12:58:06Z"^^xsd:dateTime .

obo:RO_0002418  a                    owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:label                   "causally upstream of or within" ;
        rdfs:subPropertyOf           obo:RO_0002501 ;
        obo:IAO_0000115              "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." ;
        obo:IAO_0000116              "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" ;
        obo:IAO_0000117              "Chris Mungall" ;
        obo:IAO_0000118              "influences (processual)" ;
        oboInOwl1:hasRelatedSynonym  "affects" ;
        owl:inverseOf                obo:RO_0002427 .

obo:RO_0002207  a           owl:ObjectProperty ;
        rdfs:comment        "TODO - add child relations from DOS" ;
        rdfs:domain         []  ;
        rdfs:label          "directly develops from"@en ;
        rdfs:range          []  ;
        rdfs:subPropertyOf  obo:RO_0002202 ;
        obo:IAO_0000114     obo:IAO_0000125 ;
        obo:IAO_0000115     "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." ;
        obo:IAO_0000117     "David Osumi-Sutherland" , "has developmental precursor" , "Chris Mungall" ;
        obo:IAO_0000119     "FBbt" ;
        obo:RO_0002575      obo:RO_0002202 ;
        owl:inverseOf       obo:RO_0002210 .

obo:RO_0004003  a                owl:ObjectProperty ;
        rdfs:label               "has material basis in germline mutation in" ;
        rdfs:seeAlso             <http://www.orpha.net/ORDO/Orphanet_317343> ;
        rdfs:subPropertyOf       obo:RO_0004000 ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2017-11-05T02:45:54Z"^^xsd:dateTime ;
        owl:inverseOf            obo:RO_0004013 .

obo:RO_0002575  a           owl:AnnotationProperty ;
        rdfs:label          "is direct form of" ;
        rdfs:subPropertyOf  obo:RO_0002422 ;
        obo:IAO_0000115     "relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y" ;
        obo:IAO_0000116     "The general property hierarchy is:\n\n  \"directly P\" SubPropertyOf \"P\"\n  Transitive(P)\n\nWhere we have an annotation assertion\n\n  \"directly P\" \"is direct form of\" \"P\"" ;
        obo:RO_0002423      "If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'" ;
        dc:creator          "Chris Mungall" .

obo:RO_0002630  a           owl:ObjectProperty ;
        rdfs:label          "directly negatively regulates" ;
        rdfs:subPropertyOf  obo:RO_0002578 , obo:RO_0002212 ;
        obo:IAO_0000115     "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
        obo:IAO_0000589     "directly negatively regulates (process to process)" ;
        obo:RO_0004050      obo:RO_0002578 .

obo:RO_0002545  a           owl:AnnotationProperty ;
        rdfs:label          "month of gestation" ;
        rdfs:subPropertyOf  obo:RO_0002535 ;
        obo:IAO_0000115     "Defines the start and end of a stage with a duration of 1 month, relative to either the time of fertilization or last menstrual period of the mother (to be clarified), counting from one, in terms of a reference model. Thus if month_of_gestation=3, then the stage is 2 month in." .

obo:RO_0040035  a                owl:ObjectProperty ;
        rdfs:label               "disease relationship" ;
        obo:IAO_0000115          "This relation groups  relations between diseases and any other kind of entity." ;
        obo:IAO_0000232          "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease." ;
        oboInOwl1:created_by     "cjm" ;
        oboInOwl1:creation_date  "2018-09-26T00:00:32Z"^^xsd:dateTime .

obo:RO_0002334  a           owl:TransitiveProperty , owl:ObjectProperty ;
        rdfs:domain         obo:BFO_0000015 ;
        rdfs:label          "regulated by"@en ;
        rdfs:range          obo:BFO_0000015 ;
        rdfs:subPropertyOf  obo:RO_0002427 ;
        obo:IAO_0000115     "inverse of regulates" ;
        obo:IAO_0000117     "Chris Mungall" ;
        obo:IAO_0000589     "regulated by (processual)" ;
        oboInOwl1:inSubset  obo:RO_0002259 .

obo:RO_0002600  a           owl:ObjectProperty ;
        rdfs:label          "capable of upregulating or causing pathological process" ;
        rdfs:subPropertyOf  obo:RO_0002598 ;
        obo:IAO_0000112     "benzene -> cancer [CHEBI]" ;
        obo:IAO_0000115     "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." ;
        obo:IAO_0000118     "causes disease" ;
        obo:IAO_0000119     <http://purl.obolibrary.org/obo/ro/docs/causal-relations> .

obo:RO_0002249  a           owl:ObjectProperty ;
        rdfs:label          "active ingredient in'" ;
        rdfs:subPropertyOf  obo:BFO_0000050 ;
        obo:IAO_0000115     "inverse of has active ingredient" ;
        oboInOwl1:inSubset  obo:RO_0002259 .